Results 31 to 40 of about 103,613 (63)

Long-circulating doxorubicin and Schizandrin A liposome with drug-resistant liver cancer activity: in vitro and in vivo evaluation

Journal of liposome research, 2023
Co-loading doxorubicin (DOX) and Schizandrin A (SchA) long-circulating liposome (SchA-DOX-Lip) have been confirmed to have good antitumor activity in vitro.
Shi-Yi Xu, Wei-Wei Wang, Zi-Hui Qu, Xiang Zhang, Ming Chen, Xin-yu Zhang, N. Xing, Hui Su, Xue-ying Wang, M. Cui, Xueying Yan, Wei Ma   +11 more
semanticscholar   +1 more source

Liposome-based delivery of biological drugs

Chinese Chemical Letters, 2021
Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membrane-permeability, low stability, and larger size. Liposome-
Kosheli Thapa Magar, George Frimpong Boafo, Xiaotong Li, Zhongjian Chen, Wei He   +4 more
semanticscholar   +1 more source

Carboxymethyl chitosan and octadecylamine-coated liposome-containing WPTS: design, optimization, and evaluation

Journal of liposome research, 2023
Liposomes (LPs) are a delivery system for stabilizing pharmaceuticals with limited use due to their propensity to congregate and fuse. A proposed method of addressing these problems is polymer coating. In this study, the potential of octadecylamine (ODA)-
Nan Wang, Chi Zhang, Jiahui Wu, Dachuan Zhang, Junling Li, Galvbu A, Leimengyuan Tang, Yan Li, Houxier Li, Shuting Tan, Xueyong Wang   +10 more
semanticscholar   +1 more source

Development and optimization of TPGS-based stealth liposome of doxorubicin using Box–Behnken design: characterization, hemocompatibility, and cytotoxicity evaluation in breast cancer cells

Journal of liposome research, 2021
The present work reports the development of doxorubicin (DOX) encapsulated α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated liposomal system (DOX-LIPO-TPGS) by quality by design (QbD) approach and evaluated for its anticancer and ...
B. Kurmi, S. Paliwal
semanticscholar   +1 more source

Protein-liposome interactions: the impact of surface charge and fluidisation effect on protein binding

Journal of liposome research, 2022
At the dawn of a new nanotechnological era in the pharmaceutical field, it is very important to examine and understand all the aspects that influence in vivo behaviour of nanoparticles.
E. Triantafyllopoulou, N. Pippa, C. Demetzos   +2 more
semanticscholar   +1 more source

Long-circulating doxorubicin and schizandrin A liposome with drug-resistant liver cancer activity: preparation, characterization, and pharmacokinetic

Journal of liposome research, 2021
The selectivity of chemotherapeutic agents for liver cancer is poor. When they kill tumour cells, they produce serious adverse reactions in the whole body and multidrug resistance (MDR) is also a major hurdle in liver cancer chemotherapy.
Shili Xu, Hui Su, Xingfan Zhu, Xueyan Li, Jie Li, Xi Chen, Qi Wang, R. Hao, Xueying Yan   +8 more
semanticscholar   +1 more source

The amounts of osmotic solute released by the pulsating liposome during its activity

Romanian Reports in Physics
In this paper we consider an unilamellar liposome (lipid vesicle) filled with aqueous solution of an osmotic solute. This liposome is introduced in an aqueous medium of large dimensions.
D. Popescu, Diana R. Radnef‐Constantin
semanticscholar   +1 more source

Liposome stability: multifactorial regulation and optimization strategies in in vivo delivery

Journal of liposome research
As an essential carrier for drug delivery systems, the stability of liposomes directly influences the efficiency and safety of drug delivery. In the complex and challenging process of in vivo delivery, the stability of liposomes is affected by both their
Xiaonan Lu, Li-Qing Yang, Lan Ma, Jiang-Feng Wu, Hong-Bing Zhang, Ying Wang   +5 more
semanticscholar   +1 more source

Formulation, characterization, and in vitro evaluation of lactoferrin conjugated liposome loaded with magnesium sulfate for improved CNS penetrability

Journal of liposome research
Magnesium deficiency has been reported in association with various disease conditions, particularly in neurological diseases. The limited clinical use of magnesium sulfate is due to its restricted entry into the Central Nervous system (CNS) through blood
Aparna Ann Mathew, Rajitha Panonnummal, A. A, S. M   +3 more
semanticscholar   +1 more source

Responsiveness of glycyrrhetinic acid modified liposome toward secretory phospholipase A2 and its growth inhibitory in Colo205 cells

Journal of liposome research
This study aimed to design a novel liposome containing GA modified phosphatidylcholine lipid (GA-PC Lip) and determine its susceptibility to tumor over-expressed secretory phospholipase A2 (sPLA2) and its anti-cancer effect compared to conventional ...
Zhicheng Su, Yanjiao Liu
semanticscholar   +1 more source