Results 61 to 70 of about 6,064,789 (390)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Evaluation of the Linear Relationship Between Pulse Arrival Time and Blood Pressure in ICU Patients: Potential and Limitations [PDF]

open access: yes, 2018
A variety of techniques based on the indirect measurement of blood pressure (BP) by Pulse Transit Time (PTT) have been explored over the past few years.
Braiam Escobar-Restrepo   +3 more
core   +2 more sources

Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study

open access: yesFrontiers in Endocrinology, 2017
BackgroundThe association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population ...
Yong Mao   +6 more
doaj   +1 more source

Pulse pressure and arterial elasticity [PDF]

open access: yesQJM, 2002
The last decade has seen increased interest in the mechanical interaction between the heart and the arterial system. In particular, it has been suggested that increased arterial stiffness is associated with the development of cardiovascular disease and may even predict its development at an early stage before vascular lesions or external symptoms ...
openaire   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Ear oximeter-transducer monitors four physiological responses [PDF]

open access: yes, 1972
Device monitors blood oxygen saturation, blood pressure, pulse rate, and pulse-pressure curve during conditions of high stress in simulated space ...
Smith, J. R., Jr.
core   +1 more source

Scattering of a Plane Acoustical Wave by a Spherical Obstacle [PDF]

open access: yes, 1965
The long-time behavior of the scattered field produced by a plane acoustical pulse stalking a spherical obstacle is investigated. Incident pulses are taken that represent a unit step in potential (or equivalently delta function pulse in pressure), an ...
Cohen, Donald S., Handelman, George H.
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Xenon excimer emission from pulsed high-pressure capillary microdischarges [PDF]

open access: yes, 2007
Intense xenon vacuum ultraviolet (VUV) emission is observed from a high-pressure capillary cathode microdischarge in direct current operation, by superimposing a high-voltage pulse of 50 ns duration.
Frank, Klaus   +4 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

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