Results 21 to 30 of about 14,117 (257)

Pulsed field ablation: Biophysical principles and practical considerations in atrial fibrillation treatment

Indian Pacing and Electrophysiology Journal
Pulsed field ablation (PFA) is an emerging nonthermal ablation modality for the treatment of atrial fibrillation. Unlike conventional thermal energy sources such as radiofrequency and cryoablation, PFA delivers high-voltage pulsed electric fields that ...
Shivaraj Patil, Suraj Kapa, Abhishek J. Deshmukh   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Sequential Unipolar Biventricular Pulsed Field Ablation for Refractory Intramural Septal Ventricular Tachycardia

JACC: Case Reports
Catheter ablation of septal ventricular tachycardia (VT) is challenging. Pulsed field ablation is a promising technology, potentially reaching deep substrates.
María Cespón-Fernández, MD, PhD, Luigi Pannone, MD, Domenico Della Rocca, MD, PhD, Mark La Meir, MD, PhD, Alexander Almorad, MD, Gian-Battista Chierchia, MD, PhD, Carlo de Asmundis, MD, PhD, Andrea Sarkozy, MD, PhD   +7 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

High-power-short-duration-radiofrequency-, cryoballoon-, and pulsed-field-ablation: a prospective clinical study

BMC Cardiovascular Disorders
Background Pulmonary vein isolation aims to reduce the burden of atrial fibrillation leading to symptom alleviation and improvement in quality of life.
Daniel Robinson, Hanna Seiler, Stephan Valenta, Plamen Kochev, Jakob Eichhorn, Jonas Bodanowitz, Anton Khvan, Annegret Werner, Chrisia Arnold, Christian Ewertsen, Sebastian Feickert, Burkert Pieske, Hüseyin Ince, Jasmin Ortak   +13 more
doaj   +1 more source

A Hybrid Minimally Invasive Atrial Fibrillation Ablation Procedure Using Unilateral Thoracoscopy and Endocardial Pulsed Field Ablation: An Early Feasibility Study

Journal of Cardiovascular Development and Disease
(1) Objective: To examine the efficiency and efficacy of using endovascular mapping and pulsed field ablation in the setting of a hybrid video-assisted thoracoscopic atrial fibrillation (AF) ablation procedure.
Ivan Eltsov, Luigi Pannone, Domenico Giovanni Della Rocca, Massimiliano Marini, Giacomo Talevi, Andrea Maria Paparella, Pasquale Vergara, Erwin Ströker, Juan Sieira, Gian-Battista Chierchia, Carlo de Asmundis, Mark La Meir   +11 more
doaj   +1 more source

Anaesthesia for Pulsed Field Ablation Procedures

Arrhythmia & Electrophysiology Review
Pulsed field ablation (PFA) is a novel, non-thermal technology used in catheter ablation procedures. Despite its growing clinical adoption, a standardised sedation protocol has not yet been established. Well-coordinated anaesthesia management is essential for procedural success, patient safety and comfort.
Christian-Hendrik Heeger, Natig Gassanov, Mirza Mutallimov   +2 more
openaire   +2 more sources

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Biophysics and Clinical Effectiveness of Irreversible Electroporation for Catheter Ablation of Atrial Fibrillation

Journal of Cardiovascular Development and Disease
Understanding the biophysics of electroporation—the mechanism by which pulsed electric fields achieve tissue ablation—is essential for advancing this emerging technology.
Anna-Sophie Eberl, Gernot Plank, Martin Manninger, Ursula Rohrer, Laura Stix, Stefan Kurath-Koller, Andreas Zirlik, Daniel Scherr   +7 more
doaj   +1 more source

Pulsed-Field Ablation Using a Novel Ablation-Mapping Integrated System for Pulmonary Vein Isolation—A Preliminary Animal Study

Journal of Cardiovascular Development and Disease, 2022
Objective: The purpose of this study is to evaluate the preliminary safety and effect of a pulsed electric field (PEF) ablation system. Methods: The pulmonary veins (PVs) and superior vena cava (SVC) were isolated with the pulsed field ablation (PFA ...
Zhihong Zhao, Yonggang Chen, Bin Wu, Gaodong Qiu, Liangjie Hong, Xinhua Chen, Xingwei Zhang   +6 more
doaj   +1 more source