Results 31 to 40 of about 632,550 (345)

Pulsed Field Ablation for Atrial Fibrillation: Mechanisms, Advantages, and Limitations

Reviews in Cardiovascular Medicine
Pulsed field ablation with irreversible electroporation for the treatment of atrial fibrillation involves tissue-specific and non-thermal energy-induced cell necrosis, which helps avoid complications, such as pulmonary vein stenosis, atrial collateral ...
Shali Jiang, Frank Qian, Shuting Ji, Luohong Li, Qiming Liu, Shenghua Zhou, Yichao Xiao   +6 more
doaj   +1 more source

Effect of Pulsed-Field Ablation on Human Coronary Arteries: A Longitudinal Study With Intracoronary Imaging.

JACC Clinical Electrophysiology
BACKGROUND Pulsed-field ablation (PFA) is known to cause acute coronary spasm. Whether this translates into long-term coronary artery stenosis is unknown. OBJECTIVES This study sought to evaluate changes in coronary artery after PFA for atrial flutter.
Mark T.K. Tam, J. Y. Chan, Chin-Pang Chan, E. Wu, Angel Lai, Alex C K Au, Wai-Kin Chi, Guang-Ming Tan, Bryan P. Yan   +8 more
semanticscholar   +1 more source

Efficacy and safety of novel pulsed field ablation (PFA) technique for atrial fibrillation: A systematic review and meta‐analysis

Health Science Reports, 2023
Background and Aim Pulse field ablation (PFA) has emerged as a safe alternative to other catheter ablation energy sources for patients. Although early results are encouraging, secondary data about outcomes are lacking.
Nour Shaheen, Ahmed Shaheen, Abdelraouf Ramadan, Abdulqadir J. Nashwan   +3 more
doaj   +1 more source

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Nature Medicine
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to ...
E. Ekanem, P. Neužil, T. Reichlin, J. Kautzner, P. van der Voort, P. Jais, G. Chierchia, A. Bulava, Y. Blaauw, Tomáš Skála, M. Fiala, M. Duytschaever, Gábor Széplaki, Boris Schmidt, G. Massoullié, K. Neven, O. Thomas, J. Vijgen, E. Gandjbakhch, D. Scherr, A. Johannessen, D. Keane, S. Boveda, Philippe Maury, I. García-Bolao, A. Anić, P. S. Hansen, F. Raczka, A. Lepillier, Yves Guyomar, D. Gupta, J. V. van Opstal, P. Defaye, C. Sticherling, P. Sommer, P. Kučera, J. Osca, Fariborz Tabrizi, Antoine Roux, M. Gramlich, S. Bianchi, P. Adragão, F. Solimene, Claudio Tondo, A. D. Russo, J. Schreieck, Armin Luik, O. Rana, Gerrit Frommeyer, F. Anselme, Ingo Kreis, Raphael Rosso, A. Metzner, L. Gellér, S. Baldinger, A. Ferrero, S. Willems, A. Goette, G. Mellor, S. Mathew, L. Szumowski, R. Tilz, S. Iacopino, Peter Karl Jacobsen, A. George, P. Osmančík, S. Spitzer, R. Balasubramaniam, A. Parwani, T. Deneke, A. Glowniak, A. Rossillo, H. Pürerfellner, D. Duncker, P. Reil, T. Arentz, D. Steven, J. J. Olalla, J. D. de Jong, R. Wakili, S. Abbey, Gottschling Timo, A. Asso, T. Wong, Bertrand Pierre, N. Ewertsen, L. Bergau, C. Lozano-Granero, Maximo Rivero, Alexander Breitenstein, J. Inkovaara, Samir Fareh, D. Lațcu, Dominik K Linz, Patrick Müller, J. Ramos-Maqueda, T. Beiert, S. Themistoclakis, D. Meininghaus, G. Stix, S. Tzeis, J. Baran, H. Almroth, D. Muñoz, João de Sousa, M. Efremidis, P. Balsam, J. Petru, Thomas Küffer, P. Peichl, L. Dekker, D. D. Della Rocca, O. Moravec, M. Funasako, Sébastien Knecht, G. Jauvert, J. Chun, R. Eschalier, Anna Füting, Alexandre Zhao, P. Koopman, M. Laredo, M. Manninger, J. Hansen, D. O'Hare, A. Rollin, Z. Jurišić, T. Fink, C. Chaumont, A. Rillig, Melanie Gunawerdene, Claire Martin, B. Kirstein, K. Nentwich, H. Lehrmann, Arian Sultan, J. Bohnen, M. Turagam, Vivek Y. Reddy   +138 more
semanticscholar   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pulsed-Field Ablation Using a Novel Ablation-Mapping Integrated System for Pulmonary Vein Isolation—A Preliminary Animal Study

Journal of Cardiovascular Development and Disease, 2022
Objective: The purpose of this study is to evaluate the preliminary safety and effect of a pulsed electric field (PEF) ablation system. Methods: The pulmonary veins (PVs) and superior vena cava (SVC) were isolated with the pulsed field ablation (PFA ...
Zhihong Zhao, Yonggang Chen, Bin Wu, Gaodong Qiu, Liangjie Hong, Xinhua Chen, Xingwei Zhang   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Sequential Unipolar Biventricular Pulsed Field Ablation for Refractory Intramural Septal Ventricular Tachycardia

JACC: Case Reports
Catheter ablation of septal ventricular tachycardia (VT) is challenging. Pulsed field ablation is a promising technology, potentially reaching deep substrates.
María Cespón-Fernández, MD, PhD, Luigi Pannone, MD, Domenico Della Rocca, MD, PhD, Mark La Meir, MD, PhD, Alexander Almorad, MD, Gian-Battista Chierchia, MD, PhD, Carlo de Asmundis, MD, PhD, Andrea Sarkozy, MD, PhD   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High-power-short-duration-radiofrequency-, cryoballoon-, and pulsed-field-ablation: a prospective clinical study

BMC Cardiovascular Disorders
Background Pulmonary vein isolation aims to reduce the burden of atrial fibrillation leading to symptom alleviation and improvement in quality of life.
Daniel Robinson, Hanna Seiler, Stephan Valenta, Plamen Kochev, Jakob Eichhorn, Jonas Bodanowitz, Anton Khvan, Annegret Werner, Chrisia Arnold, Christian Ewertsen, Sebastian Feickert, Burkert Pieske, Hüseyin Ince, Jasmin Ortak   +13 more
doaj   +1 more source