Results 21 to 30 of about 12,580 (254)

Catheter Ablation of Persistent AF—Where are We Now?

Reviews in Cardiovascular Medicine, 2023
Persistent atrial fibrillation (AF) is a diverse condition that includes various subtypes and underlying causes of arrhythmia. Progress made in catheter ablation technology in recent years has significantly enhanced the durability of ablation.
Louisa O’Neill, Benjamin De Becker, Maarten A.J. De Smet, Clara Francois, Jean-Benoit Le Polain De Waroux, Rene Tavernier, Mattias Duytschaever, Sebastien Knecht   +7 more
doaj   +1 more source

Myocardial electroporation — an alternative to thermal methods of atrial fibrillation treatment

Рациональная фармакотерапия в кардиологии, 2023
Atrial fibrillation is one of the most common cardiac arrhythmias. By all estimates, the number of patients with this arrhythmia will only increase. Currently, the main and most used methods for the treatment of atrial fibrillation are radiofrequency and
E. A. Archakov, R. E. Batalov, M. S. Khlynin, A. V. Smorgon, S. V. Popov   +4 more
doaj   +1 more source

Pulsed Field Ablation for Atrial Fibrillation: Mechanisms, Advantages, and Limitations

Reviews in Cardiovascular Medicine
Pulsed field ablation with irreversible electroporation for the treatment of atrial fibrillation involves tissue-specific and non-thermal energy-induced cell necrosis, which helps avoid complications, such as pulmonary vein stenosis, atrial collateral ...
Shali Jiang, Frank Qian, Shuting Ji, Luohong Li, Qiming Liu, Shenghua Zhou, Yichao Xiao   +6 more
doaj   +1 more source

Efficacy and safety of novel pulsed field ablation (PFA) technique for atrial fibrillation: A systematic review and meta‐analysis

Health Science Reports, 2023
Background and Aim Pulse field ablation (PFA) has emerged as a safe alternative to other catheter ablation energy sources for patients. Although early results are encouraging, secondary data about outcomes are lacking.
Nour Shaheen, Ahmed Shaheen, Abdelraouf Ramadan, Abdulqadir J. Nashwan   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pulsed-Field Ablation Using a Novel Ablation-Mapping Integrated System for Pulmonary Vein Isolation—A Preliminary Animal Study

Journal of Cardiovascular Development and Disease, 2022
Objective: The purpose of this study is to evaluate the preliminary safety and effect of a pulsed electric field (PEF) ablation system. Methods: The pulmonary veins (PVs) and superior vena cava (SVC) were isolated with the pulsed field ablation (PFA ...
Zhihong Zhao, Yonggang Chen, Bin Wu, Gaodong Qiu, Liangjie Hong, Xinhua Chen, Xingwei Zhang   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Sequential Unipolar Biventricular Pulsed Field Ablation for Refractory Intramural Septal Ventricular Tachycardia

JACC: Case Reports
Catheter ablation of septal ventricular tachycardia (VT) is challenging. Pulsed field ablation is a promising technology, potentially reaching deep substrates.
María Cespón-Fernández, MD, PhD, Luigi Pannone, MD, Domenico Della Rocca, MD, PhD, Mark La Meir, MD, PhD, Alexander Almorad, MD, Gian-Battista Chierchia, MD, PhD, Carlo de Asmundis, MD, PhD, Andrea Sarkozy, MD, PhD   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High-power-short-duration-radiofrequency-, cryoballoon-, and pulsed-field-ablation: a prospective clinical study

BMC Cardiovascular Disorders
Background Pulmonary vein isolation aims to reduce the burden of atrial fibrillation leading to symptom alleviation and improvement in quality of life.
Daniel Robinson, Hanna Seiler, Stephan Valenta, Plamen Kochev, Jakob Eichhorn, Jonas Bodanowitz, Anton Khvan, Annegret Werner, Chrisia Arnold, Christian Ewertsen, Sebastian Feickert, Burkert Pieske, Hüseyin Ince, Jasmin Ortak   +13 more
doaj   +1 more source