Results 101 to 110 of about 19,879 (260)

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin   +13 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

open access: yesAdvanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li   +5 more
wiley   +1 more source

Deep Eutectic Polymer Electrolyte with Competitive Hydrogen‐Bonding Coordination for High‐Voltage Nickel‐rich Lithium Metal Batteries

open access: yesAdvanced Science, EarlyView.
To stabilize high‐voltage Li||NCM811 batteries, we develop an in situ polymerized deep‐eutectic electrolyte (p‐DEPE) featuring competitive hydrogen‐bonding coordination. This design weakens Ni4+ adsorption, suppresses oxygen release, and enhances interfacial stability.
Yuxin Fan   +6 more
wiley   +1 more source

Scalp acupuncture targets for neurological disorders:evidence from neuroimaging studies (part 1)

open access: yes针刺研究
ObjectiveScalp acupuncture is a unique acupuncture method developed based on brain functional and pathophysiological knowledge. In past decades, there has been significant development in the understanding of the brain pathology of many neurological ...
ZHANG Bin-long   +6 more
doaj  

A Study on Central Neurotransmitter Mechanism of the Effect of Puncturing the Superficial Blood Vessel of the Twelve Jing Points of Forepaws and Electroacupuncture on the Rheoencephalogram in Rabbits

open access: yes针刺研究, 1998
This study used a method of injecting receptor blocking agants into ventricles of rabbit's brain to observe the effect of electroacupuncture and blood-letting puncturing at the twelve jing points of forepaws on rabbit's rheoencephalogram and to discuss ...
Zhou Zhiliang
doaj  

Dural Puncture Epidural: to puncture or not to puncture?

open access: yes, 2021
De Haes, J.   +3 more
openaire   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

open access: yesAdvanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz   +4 more
wiley   +1 more source

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu   +10 more
wiley   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

open access: yesAdvanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li   +7 more
wiley   +1 more source

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