Results 61 to 70 of about 2,690 (129)

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, Volume 40, Issue 4, Page 2003-2024, April 2026.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation

Drug Design, Development and Therapy, 2021
Ebtesam A Mohamad,1 Aya A Aly,2 Aya A Khalaf,2 Mona I Ahmed,2 Reham M Kamel,2 Sherouk M Abdelnaby,2 Yasmine H Abdelzaher,2 Marize G Sedrak,2 Shaker A Mousa3 1Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt; 2Biotechnology ...
Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA   +8 more
doaj  

Punicalagin, a pomegranate polyphenol sensitizes the activity of antibiotics against three MDR pathogens of the Enterobacteriaceae

BMC Complementary Medicine and Therapies
Background Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The discovery of new antimicrobials having the reversing drug resistance potential may contribute to augment and revive ...
Saba Kiran, Anam Tariq, Shoaib Iqbal, Zubera Naseem, Waqar Siddique, Sobia Jabeen, Rizwan Bashir, Ashfaq Hussain, Moazur Rahman, Fazal-e Habib, Waqar Rauf, Aamir Ali, Yasra Sarwar, Georg Jander, Mazhar Iqbal   +14 more
doaj   +1 more source

In vitro steatosis hepatic cell model to compare the lipid-lowering effects of pomegranate peel polyphenols with several other plant polyphenols as well as its related cholesterol efflux mechanisms

Toxicology Reports, 2014
This study was aimed to compare the relative activities of the purified pomegranate peels polyphenols (PPPs) with some other plant polyphenols including punicalagin, ellagic acid, gallic acid, phlorizin, and epigallocatechin gallate (EGCG) on the lipid ...
Wei Zhao, Jianke Li, Xiaoye He, Ou Lv, Yujiang Cheng, Run Liu   +5 more
doaj   +1 more source

Punicalagin Protects Ram Sperm from Oxidative Stress by Enhancing Antioxidant Capacity and Mitochondrial Potential during Liquid Storage at 4 °C

Animals
The aim of this study was to investigate the effect of punicalagin, an antioxidant, on ram sperm quality. Semen samples were collected and pooled from five rams, then diluted using a Tris-based diluent containing various concentrations (0, 5, 15, 30 and ...
Liuming Zhang, Xuyang Wang, Tariq Sohail, Caiyu Jiang, Yuxuan Sun, Jian Wang, Xiaomei Sun, Yongjun Li   +7 more
doaj   +1 more source

Pomegranate Peel Extract Microemulsions for Skin Delivery: Insights into Drug Release, Skin Permeation and UV Protection

Cosmetics
Pomegranate peel, an abundant agro-industrial by-product, represents a sustainable source of bioactive polyphenols, particularly punicalagin, which has been associated with antioxidant and photoprotective potential.
Nataša Bubić Pajić, Teodora Trninić, Darija Knežević Ratković, Vesna Antunović, Katarina Šavikin, Jelena Živković, Ranko Škrbić   +6 more
doaj   +1 more source

Computational investigations of potential inhibitors of monkeypox virus envelope protein E8 through molecular docking and molecular dynamics simulations

Scientific Reports
The World Health Organization (WHO) has declared the monkeypox outbreak a public health emergency, as there is no specific therapeutics for monkeypox virus (MPXV) disease. This study focused on docking various commercial drugs and plant-derived compounds
Rohit Das, Anil Bhattarai, Rohit Karn, Buddhiman Tamang   +3 more
doaj   +1 more source

Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model—Possible Effects of Punicalagin

Organoids
Osteosarcomas are the most common primary malignant bone tumors and mostly affect children, adolescents, and young adults. Despite current treatment options such as surgery and polychemotherapy, the survival of patients with metastatic disease remains ...
Anna Rebecca Dorn, Sara Neff, Sophia Hupp, Melissa Engelhardt, Eric Pion, Ulrich Lenze, Carolin Knebel, Anna Duprée, Simone Schewe, Markus Weber, Christian Wulbrand, Axel Hillmann, Florian Weber, Phillip Clarke, Philipp Kainz, Thiha Aung, Silke Haerteis   +16 more
doaj   +1 more source

The polyphenolic compound punicalagin protects skin fibroblasts from UVA radiation oxidative damage

Current Research in Pharmacology and Drug Discovery
Polyphenols are a class of natural compounds that act as antioxidants, neutralising harmful free radicals that would damage cells and increase the risk of diseases such as cancer, diabetes and heart disease.
Giada Bianchetti, Patrizia Bottoni, Giuseppe Tringali, Giuseppe Maulucci, Elisabetta Tabolacci, Maria Elisabetta Clementi   +5 more
doaj   +1 more source

Study on the Effects of Tannase on the De Astringency of Pomegranate Juice

Foods
Reducing the punicalagin content is an effective strategy for eliminating the astringency of pomegranate juice. In this study, pomegranate juice was used as the raw material, and tannase was applied to convert punicalagin into ellagic acid and gallic ...
Guida Zhu, Longwen Wang, Han Wang, Zihan Chen, Xue Li, Yi Ji, Jing Yu, Ping Song   +7 more
doaj   +1 more source