Results 81 to 90 of about 2,738 (165)

Dual hypopigmentary effects of punicalagin via the ERK and Akt pathways

Biomedicine & Pharmacotherapy, 2017
Punicalagin is a phenolic compound with antioxidant properties. However, the effects of punicalagin on melanin synthesis have been poorly evaluated. Therefore, we investigated the effects of punicalagin on melanogenesis in Mel-Ab cells. Punicalagin significantly inhibited melanin synthesis in a dose-dependent manner.
Jun Seob Shin, Jun Hee Cho, Hana Lee, Hyo-Soon Jeong, Myo-Kyoung Kim, Hye-Young Yun, Nyoun Soo Kwon, Dong-Seok Kim   +7 more
openaire   +2 more sources

Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Mingcheng Huang,1,* Keping Wu,1,* Shan Zeng,2,* Wenfen Liu,1 Tianjiao Cui,1 Zhiqing Chen,1 Lian Lin,1 Dongying Chen,3 Hui Ouyang1 1Department of Nephrology, Kidney and Urology Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, ShenZhen ...
Huang M, Wu K, Zeng S, Liu W, Cui T, Chen Z, Lin L, Chen D, Ouyang H   +8 more
doaj  

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, Volume 40, Issue 4, Page 2003-2024, April 2026.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Optimization of Hot and Cold‐Water Extractions of Cistus salviifolius L. for Enhanced Phenolic Content and Antimicrobial Efficacy

ChemistrySelect, Volume 11, Issue 13, 6 April 2026.
This study optimized cold and hot water extractions for maximizing phenolic content and antibacterial activity against S. aureus and P. aeruginosa. Hot water yielded higher total phenolics and were more effective against P. aeruginosa. Conversely, cold water enriched specific ellagitannins (punicalagin and cistusin), showing potent, targeted ...
Atalanti Christou, Alexandra Charilaou, Danae Markou, Nikolaos A. Parisis, Panayiota Piri, Konstantina Stavrou, Andreas G. Tzakos, George Botsaris, Ioannis P. Gerothanassis, Vlasios Goulas   +9 more
wiley   +1 more source

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation

Drug Design, Development and Therapy, 2021
Ebtesam A Mohamad,1 Aya A Aly,2 Aya A Khalaf,2 Mona I Ahmed,2 Reham M Kamel,2 Sherouk M Abdelnaby,2 Yasmine H Abdelzaher,2 Marize G Sedrak,2 Shaker A Mousa3 1Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt; 2Biotechnology ...
Mohamad EA, Aly AA, Khalaf AA, Ahmed MI, Kamel RM, Abdelnaby SM, Abdelzaher YH, Sedrak MG, Mousa SA   +8 more
doaj  

Punicalagin, a pomegranate polyphenol sensitizes the activity of antibiotics against three MDR pathogens of the Enterobacteriaceae

BMC Complementary Medicine and Therapies
Background Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The discovery of new antimicrobials having the reversing drug resistance potential may contribute to augment and revive ...
Saba Kiran, Anam Tariq, Shoaib Iqbal, Zubera Naseem, Waqar Siddique, Sobia Jabeen, Rizwan Bashir, Ashfaq Hussain, Moazur Rahman, Fazal-e Habib, Waqar Rauf, Aamir Ali, Yasra Sarwar, Georg Jander, Mazhar Iqbal   +14 more
doaj   +1 more source

In vitro steatosis hepatic cell model to compare the lipid-lowering effects of pomegranate peel polyphenols with several other plant polyphenols as well as its related cholesterol efflux mechanisms

Toxicology Reports, 2014
This study was aimed to compare the relative activities of the purified pomegranate peels polyphenols (PPPs) with some other plant polyphenols including punicalagin, ellagic acid, gallic acid, phlorizin, and epigallocatechin gallate (EGCG) on the lipid ...
Wei Zhao, Jianke Li, Xiaoye He, Ou Lv, Yujiang Cheng, Run Liu   +5 more
doaj   +1 more source

Punicalagin Protects Ram Sperm from Oxidative Stress by Enhancing Antioxidant Capacity and Mitochondrial Potential during Liquid Storage at 4 °C

Animals
The aim of this study was to investigate the effect of punicalagin, an antioxidant, on ram sperm quality. Semen samples were collected and pooled from five rams, then diluted using a Tris-based diluent containing various concentrations (0, 5, 15, 30 and ...
Liuming Zhang, Xuyang Wang, Tariq Sohail, Caiyu Jiang, Yuxuan Sun, Jian Wang, Xiaomei Sun, Yongjun Li   +7 more
doaj   +1 more source

The Role of Punicalagin in Slowing Down the Decaying of Neurons

Malaysian Journal of Medical and Biological Research, 2017
Punicalagin is an active compound found in the Pomegranate rind. The hallmark of the compound is its antioxidant properties which is more than most other sources such as Red wine. The poly-phenol donates hydrogen to free radicals like peroxynitrites and prevents it from oxidizing and destroying microglial cells in the brain.
openaire   +1 more source

Anti‐inflammatory effects of punicalagin on LPS‐activated microglia

The FASEB Journal, 2019
Pomegranate ( Punica granatum L.) is a popular fruit originated in the Middle East and has been widely planted around the world. It contains various phytochemicals such as polyphenolic compounds and has a wide range of biological activities, including anti‐inflammatory, anti‐tumor ...
Yueh‐Shan Lee, Yi‐Xin Lai, Chia‐Yang Li   +2 more
openaire   +1 more source