Results 61 to 70 of about 2,761 (165)

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Punicalagin and Ketogenic Amino Acids Loaded Organic Lipid Carriers Enhance the Bioavailability, Mitochondrial β-Oxidation, and Ketogenesis in Maturing Adipocytes

Nanomaterials, 2022
The identification of lipolytic bioactive compounds via the functional stimulation of carbohydrate response element-binding protein-1 (CREBp-1) and AMP-activated protein kinase (AMPK) is most warranted.
Pandurangan Subash-Babu, Nouf Al-Numair, Tahani Almuzaini, Jegan Athinarayanan, Ali Abdullah Alshatwi   +4 more
doaj   +1 more source

Potential role of punicalagin against oxidative stress induced testicular damage

Asian Journal of Andrology, 2016
Punicalagin is isolated from pomegranate and widely used for the treatment of different diseases in Chinese traditional medicine. This study aimed to evaluate the effect of Punicalagin (purity ≥98%) on oxidative stress induced testicular damage and its ...
Faiza Rao, Hui Tian, Wenqing Li, Helong Hung, Fei Sun   +4 more
doaj   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Comparative analysis of the phenolic contents and antioxidant activities of different parts of two pomegranate (Punica granatum L.) Cultivars: ‘Tunisia’ and ‘Qingpi’

Frontiers in Plant Science, 2023
Pomegranate (Punica granatum L.), with its abundant phenolic substances and strong antioxidant activity, holds significant research and utilization potential across various organs.
Huifen Zhang, Miao Wang, Guoqiang Yu, Jing Pu, Kun Tian, Xiaofu Tang, Ying Du, Hongxia Wu, Jiong Hu, Xian Luo, Lijin Lin, Qunxian Deng   +11 more
doaj   +1 more source

Polyphenolic Components and Phytochemicals Deployed as Nutraceuticals and Pharmafoods

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This review (2010–2025) highlights the therapeutic potential of dietary polyphenols against cancer, diabetes, cardiovascular, neurological, and inflammatory diseases. It summarizes molecular mechanisms, clinical evidence, nanoparticle‐based delivery, bioavailability, safety, toxicity, and future prospects supporting polyphenols as promising therapeutic
Subhash Chandra, Md. Sakib Al Hasan, Md. A. K. Azad, Atasi Goswami   +3 more
wiley   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, Volume 40, Issue 7, Page 4588-4610, July 2026.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Synergistic Effects of Carrier Composition and Spray‐Drying Conditions on the Microencapsulation of Pomegranate Peel Extract

Journal of Food Process Engineering, Volume 49, Issue 7, July 2026.
Spray drying conditions and carrier composition significantly affected the retention of bioactive compounds in pomegranate peel extract powders. The synergistic combination of maltodextrin and gum arabic enhanced process yield, ellagic acid retention, total phenolic content, and antioxidant activity under optimized drying conditions.
Nida Pınarbaşı, Aslı Arslan Kulcan, Ferhan Balcı‐Torun, Ayhan Topuz   +3 more
wiley   +1 more source

Evaluation of Punicalagin Niosomes for Skin Aging

, 2021
Skin aging is one of the most common problems facing humanity. It occurs because of altering the balance between free radicals and antioxidants and increasing the amount of the reactive oxygen species (ROS) in skin cells, which leads to oxidative stress especially when exposed to UV radiation. Antioxidants can neutralize the harmful effects of ROS, and
Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona I. Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa   +8 more
openaire  

Anticancer effects of punicalagin and 5-fluorouracil on laryngeal squamous cell carcinoma: an in vitro study

Italian Journal of Medicine
The purpose of this study was to assess the apoptotic effects of punicalagin alone and in combination with 5-fluorouracil (5-FU) on laryngeal squamous cell carcinoma (Hep-2) cell line.
Amany M. Taha, Eman Abd-Elshafy, Asmaa M. Khalifa, Najla Dar-Odeh, Shadia Elsayed, Daniah S. Alharkan, Aishah Alhodhodi, Ahmed Mohammed Sapri, Yassmeen SalahEldin Ragheb, Gihan A. Balbola   +9 more
doaj   +1 more source