Results 61 to 70 of about 13,497 (266)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Trust and Consumers’ Purchase Intention in a Social Commerce Platform: A Meta-Analytic Approach

SAGE Open, 2022
E-commerce and social media integration are becoming increasingly popular throughout the world, particularly with the emergence of Web 2.0 technology. In a social commerce (SC) environment, trust also plays a vital role in consumers’ purchase intentions.
Jian Wang, Fakhar Shahzad, Zeeshan Ahmad, Muhammad Abdullah, Nadir Munir Hassan   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The nexus between utilitarian and hedonic motivations, online shopping satisfaction, and purchase intentions [PDF]

Journal of the Academy of Business and Emerging Markets
This study examines the nexus between utilitarian and hedonic motivations, online shopping satisfaction, and purchase intentions, focusing on the mediating role of online shopping satisfaction.
Ephrem Habtemichael Redda
doaj   +1 more source

Selection Attributes of Innovative Digital Platform-Based Subscription Services: A Case of South Korea

Journal of Open Innovation: Technology, Market and Complexity, 2020
This study aimed to make an empirical analysis of the effects that the selection attributes of subscription services have on purchase intentions and continuous use intentions, based on the perceived value of digital platform-based subscription service ...
Yoojin Kim, Boyoung Kim
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pengaruh Iklan Media Sosial Instagram Terhadap Niat Beli Konsumen pada Perusahaan Jasa Travel ZTRANS Shuttle 

Jurnal Manajemen dan Bisnis Kreatif
This research is motivated by the development of digital technology that is changing the marketing landscape, particularly through social media. Social media advertising is expected to enhance consumers' purchase intentions, especially for the travel ...
Fauzian Alief Dermawan, Angga Dewi Anggraeni, Kiagus Muhammad Amran   +2 more
doaj   +1 more source

The effect of influencers on consumers' purchasing intention of Jordanian entrepreneurs' start-ups [PDF]

International Journal of Data and Network Science
Nowadays, influencers play a crucial role in product and/or service promotion as well as in purchase intention and decision-making. Therefore, the present study aims to explore the effect of influencers on consumers' purchasing intention of ...
Ahmad Yacoub Nasereddin, Shafig Haddad, Abdel-Aziz Ahmad Sharabati, Noor Elayyan, Mohammed Khasawneh   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source