Results 51 to 60 of about 336,838 (308)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Perilaku belanja online dan niat beli pada generasi “Z” di Indonesia

Journal of Business & Banking
Generation Z that dominates the population and the development of e-commerce has changed their shopping patterns, especially in terms of purchase intention. For example they choose to shop online.
Soni Harsono, Nathan Tidiend Haripraditya, Much Aji Rochman Soleh   +2 more
doaj   +1 more source

Trust and Consumers’ Purchase Intention in a Social Commerce Platform: A Meta-Analytic Approach

SAGE Open, 2022
E-commerce and social media integration are becoming increasingly popular throughout the world, particularly with the emergence of Web 2.0 technology. In a social commerce (SC) environment, trust also plays a vital role in consumers’ purchase intentions.
Jian Wang, Fakhar Shahzad, Zeeshan Ahmad, Muhammad Abdullah, Nadir Munir Hassan   +4 more
doaj   +1 more source

Pengaruh Kelompok Acuan Terhadap Sikap Dan Niat Pembelian Serta Dampaknya Pada Keputusan Pembelian (Survei Pada Konsumen Di Rumah Makan Kimbap Rina, Malang) [PDF]

, 2016
This study aims to identify and explain: the influence of the Attitude Reference Group; influence Reference Group on Purchase Intentions; Reference Group influence on purchase decision; influence Attitudes to Purchase Intentions; Attitudes influence on ...
Suharyono, S. (Suharyono), Yulianto, E. (Edy), Zahra, N. H. (Nadiastika)   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Power of social media influencers on brand awareness, value, and consumer purchases [PDF]

Spanish Journal of Marketing-ESIC
PurposeThis study aims to examine the influencer power in shaping consumer purchase intentions. It revolves around the impact of social media influencer (SMI) endorsements on purchase intentions by undertaking the mediating effects of brand awareness and
Tanya Munir, Sean Watts
doaj   +1 more source

Selection Attributes of Innovative Digital Platform-Based Subscription Services: A Case of South Korea

Journal of Open Innovation: Technology, Market and Complexity, 2020
This study aimed to make an empirical analysis of the effects that the selection attributes of subscription services have on purchase intentions and continuous use intentions, based on the perceived value of digital platform-based subscription service ...
Yoojin Kim, Boyoung Kim
doaj   +1 more source

"Green Purchase Intentions Of Romanian Consumers " [PDF]

Annales Universitatis Apulensis Series Oeconomica, 2013
This study examines the green purchase intentions of Romanian consumers. Thepurpose of this paper is to identify major factors that affect Romanian consumers' greenpurchasing behaviour . Variables that influence purchasing decisions considered in the study are:Perceived Product Price, Perceived Product Quality, Organization‘s Green Image ...
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source