Results 91 to 100 of about 1,148,210 (288)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

STRATEGIC PURCHASING IN A PROJECT- BASED COMPANY – TO CENTRALIZE OR DECENTRALIZE [PDF]

open access: yesActa Logistica, 2014
Organizations all lie on a spectrum, at one end of which are firms with complete centralization of purchasing, and at the other end are firms with complete decentralization.
Eva Donociková
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Cost management in metallurgical production

open access: yesMetalurgija, 2012
Price changes in the global raw material markets significantly infl uence the economic characteristics of Czech metallurgical companies as well. This article illustrates the utilization of changeable market situation when purchasing of raw materials infl
K. Janovská   +5 more
doaj  

Gender Differences and Consumer Behavior of Millennials

open access: yesActa Economica et Turistica, 2017
Millennial generation is considered the largest and best educated and therefore presents challenges to marketers. This paper aims to examine the gender differences in consumer behaviour of students - generation y.
Kraljević Radojka, Filipović Zrinka
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Knowledge of UK Residents About Importing Puppies from EU Countries

open access: yesAnimals
The number of puppies imported to the United Kingdom (UK) from the European Union (EU) is increasing, as are concerns about the legality, welfare and potential disease risks associated with their trade. This study aimed to use an online survey to collect
Zoe Belshaw, Rowena M. A. Packer
doaj   +1 more source

Library purchasing consortia: achieving value for money and shaping the emerging electronic marketplace [PDF]

open access: yes, 1998
Drawing on a current study, funded by the British Library Research and Innovation Centre, the context of higher education libraries is discussed, including funding and costs and recent major official reports on education and libraries.
Ball, David, Pye, Jo
core  

Purchasing in relation to purchasing logistics and purchasing marketing

open access: yesContemporary Economy, 2011
Purchasing is the management of the company’s external resources in such way that the supply of all goods and services which are necessary for running, maintaining and managing the company’s primary and support activities is secured at the most favourable conditions.
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

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