Results 61 to 70 of about 5,879,169 (309)

Toward a reduced use of pesticides in European farming systems: An introduction to the PURE project

, 2017
PURE (Pesticide Use-and-risk Reduction in European farming systems with Integrated Pest Management),a large collaborative project funded by the EU, has designed and tested IPM solutions both onstationand on-farm.
Lescourret, Francoise
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optimal pure strategies for a discrete search game

European Journal of Operational Research
Consider a two-person zero-sum search game between a Hider and a Searcher. The Hider chooses to hide in one of $n$ discrete locations (or "boxes") and the Searcher chooses a search sequence specifying which order to look in these boxes until finding the Hider.
Thuy Bui, Thomas Lidbetter, Kyle Y. Lin
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Digitaalisen markkinoinnin strategia Pure Lifestyle -verkkokaupalle [PDF]

, 2022
Tämä opinnäytetyö on luonteeltaan toiminnallinen ja se on toteutettu toimeksiantona suomalaiselle mikroyritys Pure Lifestyle Finland Oy:n verkkokaupalle nimeltään Pure Lifestyle.
Nyblom, Inka
core  

Musculoskeletal surgeons use mixed reasoning rather than pure Bayesian strategies in clinical practice.

PLoS ONE
ObjectivesTo inform efforts to promote regular and normalized Bayesian reasoning, we studied factors associated with the degree to which surgeons use Bayesian reasoning to navigate uncertainty across different clinical scenarios.MethodsScience of ...
Robert Parisien, Alexander Drost, Amin Razi, Sina Ramtin, David Ring, Stein J Janssen   +5 more
doaj   +1 more source

The Game of Pure Strategy is solved!

CoRR, 2012
We solve the classical "Game of Pure Strategy" using linear programming. We notice an intricate even-odd behavior in the results of our computations, that seems to encourage odd or maximal bids.
Glenn C. Rhoads, Laurent Bartholdi
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Bilevel programming methods for computing single-leader-multi-follower equilibria in normal-form and polymatrix games

EURO Journal on Computational Optimization, 2020
The concept of leader-follower (or Stackelberg) equilibrium plays a central role in a number of real-world applications bordering on mathematical optimization and game theory.
Nicola Basilico, Stefano Coniglio, Nicola Gatti, Alberto Marchesi   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source