Results 81 to 90 of about 4,765,884 (305)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

OPTIMAL TIMING STRATEGIES IN BLOCKCHAIN BLOCK PROPOSALS BY ONE-BULLET SILENT DUELS WITH ONE-THIRD PROGRESSION

Information and Telecommunication Sciences
Background. Silent duels and related timing games offer a surprisingly deep lens into certain core challenges in blockchain technology, especially when it comes to block proposal timing. Miners or validators effectively “compete” in a race to propose the
Вадим Романюк
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Pure Strategy Equilibria of Multidimensional and Non-Monotonic Auctions [PDF]

We give necessary and sufficient conditions for the existence of symmetric equilibrium without ties in common values auctions, with multidimensional independent types and no monotonic assumptions.
Luciano I. de Castro Filho, Aloisio Araujo   +1 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

On the existence of pure strategy equilibria in large generalized games with atomic players [PDF]

We consider a game with a continuum of players where only a finite number of them are atomic. Objective functions and admissible strategies may depend on the actions chosen by atomic players and on aggregate information about the actions chosen by non ...
Riascos Villegas, Alvaro, Torres-Martínez, Juan Pablo   +1 more
core  

Comparative Analysis Of Aggregate Production Planning Strategies (Pure Level, Chase, and Mixed) In The Gum Rosin And Turpentine Industry

Jurnal Civil Engineering Study
This study analyzes and compares three aggregate production planning (APP) strategies—Pure Level, Chase, and Mixed Strategy—in a gum rosin and turpentine industry characterized by seasonal raw material availability and fluctuating demand.
Taftsa Aulia Gholamreza Rahman, Ahmad Mubin   +1 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Oxide-dispersion-enabled laser additive manufacturing of high-resolution copper

Nature Communications
Laser additive manufacturing of pure copper (Cu) with complex geometries opens vast opportunities for the development of functional devices in microelectronics and telecommunication.
Shuo Qu, Liqiang Wang, Shengbiao Zhang, Chenfeng Yang, Hou Yi Chia, Gengbo Wu, Zongxin Hu, Junhao Ding, Wentao Yan, Yang Zhang, Chi Hou Chan, Wen Chen, Yang Lu, Xu Song   +13 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source