Results 111 to 120 of about 24,465 (266)

Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401

iMetaOmics, Volume 1, Issue 2, December 2024.
The colonic microenvironment of neonatal rats was altered after administration of the peripheral 5‐hydroxytryptamine (5‐HT) inhibitor LP533401, resulting in increased crypt depth and decreased myenteric thickness. Multi‐omics approaches, including metagenomics, transcriptomics, and metabolomics, in combination with immunofluorescence, were employed to ...
Yidan Ling, Ziyu Liu, Shuibing Han, Haiqin Wu, Chunlong Mu, Weiyun Zhu   +5 more
wiley   +1 more source

Different elemental stoichiometries of Fe‐limited Trichodesmium when grown under inorganic and organic phosphorus sources

Limnology and Oceanography, Volume 69, Issue 12, Page 2881-2895, December 2024.
Abstract Trichodesmium spp. is a colonial diazotrophic cyanobacterium found in the oligotrophic (sub)tropical oceans, where its distribution is strongly regulated by the availability of phosphorus and iron. The bulk carbon : nitrogen : phosphorus elemental composition of phytoplankton has previously been shown to depart from classical “Redfield” values
Xuechao Wang, Thomas J. Browning, Eric P. Achterberg, Martha Gledhill   +3 more
wiley   +1 more source

Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology [PDF]

, 2019
Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal ...
Albasanz, José Luis, Alonso-Andrés, Patricia, Ferrer, Isidro (Ferrer Abizanda), Martín, Mairena   +3 more
core   +1 more source

A purine nucleoside phosphorylase in Solanum tuberosum L. (potato) with specificity for cytokinins contributes to the duration of tuber endodormancy.

Biochemical Journal, 2014
StCKP1 (Solanum tuberosum cytokinin riboside phosphorylase) catalyses the interconversion of the N9-riboside form of the plant hormone CK (cytokinin), a subset of purines, with its most active free base form.
J. R. Bromley, Barbara J Warnes, C. Newell, Jamie C P Thomson, C. James, C. Turnbull, D. Hanke   +6 more
semanticscholar   +1 more source

Therapeutic potential of Parabacteroides distasonis in gastrointestinal and hepatic disease

MedComm, Volume 5, Issue 12, December 2024.
This review illustrate the metabolic network medicated by Parabacteroides distasonis and its role and action mechanism in gastrointestinal and hepatic disease. The natural components affecting Parabacteroides distasonis was summarized, which show the therapeutic potential for gastrointestinal and hepatic diseases. Abstract Increasing evidences indicate
Jingyi Duan, Qinmei Li, Yan Cheng, Weifeng Zhu, Hongning Liu, Fei Li   +5 more
wiley   +1 more source

Immunodeficiency and autoimmunity: companions not opposites

The Journal of Clinical Investigation, 2022
Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune ...
David A. Fox
doaj   +1 more source

The role of adenine nucleotides and their derivatives in the control of liver metabolism [PDF]

, 1980
Imperial Users ...
Sharma, Ravi Janak, Sharma, Ravi Janak
core  

Halogenated Adenine and Adenosine Natural Products in Streptomyces sp. JCM9888

European Journal of Organic Chemistry, Volume 27, Issue 43, November 18, 2024.
It is demonstrated that the chlorine containing dealanylascamycin producer Streptomyces sp. JCM9888 has a capacity also to brominate to generate C‐2 halogenated adenines and adenosines as well as brominated dealanylascamycin. It is noted that halogenation can occur independently of sulfamoyl moiety assembly. Abstract Ascamycin 1 and dealanylascamycin 2
Yawen Chen, Phillip T. Lowe, Hai Deng, David O'Hagan   +3 more
wiley   +1 more source

Cytotoxic Activity of Distinct Families of Phosphonic Acid Derivatives – A Chemocentric Approach to Assess Their Molecular Action

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
Phosphonates represent unique chemical space among the biologically active compounds. Several compounds were measured on various human cancer cell lines and many of them showed remarkable cytotoxic activities. To assess their potential protein targets the structure of the hits were compared with known agents annotated with targets using fingerprint ...
György Dormán, Zsuzsanna Szalai, György Keglevich   +2 more
wiley   +1 more source

Aeromonas hydrophila strains as biocatalysts for transglycosylation [PDF]

, 2010
Microbial transglycosylation is useful as a green alternative in the preparation of purine nucleosides and analogues, especially for those that display pharmacological activities.
Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra, Nóbile, Matías Leonardo, Terreni, Marco   +3 more
core   +1 more source