Results 141 to 150 of about 24,465 (266)

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. [PDF]

J Med Chem, 2023
Skácel J, Djukic S, Baszczyňski O, Kalčic F, Bílek T, Chalupský K, Kozák J, Dvořáková A, Tloušt'ová E, Král'ová Z, Šmídková M, Voldřich J, Rumlová M, Pachl P, Brynda J, Vučková T, Fábry M, Snášel J, Pichová I, Řezáčová P, Mertlíková-Kaiserová H, Janeba Z.   +21 more
europepmc   +1 more source

Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder. [PDF]

, 1981
Alan R. Watson, D I Evans, H. B. Marsden, Vanessa Miller, Pauline Rogers   +4 more
openalex   +1 more source

Still a long way to fully understanding the molecular mechanism of Escherichia coli purine nucleoside phosphorylase

, 2013
The results of several decades of studying the catalytic mechanism of Escherichia colt purine nucleoside phosphorylases (PNP) by solution studies and crystal structure determinations are presented.
Z. Štefanić, Goran Mikleušević, M. Narczyk, B. Wielgus-Kutrowska, A. Bzowska, M. Luić   +5 more
semanticscholar   +1 more source

purine nucleoside phosphorylase

Catalysis from A to Z, 2020

semanticscholar   +2 more sources

Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme. [PDF]

Int J Mol Sci, 2023
Dyzma A, Wielgus-Kutrowska B, Girstun A, Matošević ZJ, Staroń K, Bertoša B, Trylska J, Bzowska A.   +7 more
europepmc   +1 more source

Investigation of α-deuterium kinetic isotope effects on the purine nucleoside phosphorylase reaction by the equilibrium-perturbation technique [PDF]

, 1989
Pertti Lehikoinen, Michael L. Sinnott, Thomas A. Krenitsky   +2 more
openalex   +1 more source

Correction: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. [PDF]

PLoS Pathog, 2022
Tecle E, Chhan CB, Franklin L, Underwood RS, Hanna-Rose W, Troemel ER.   +5 more
europepmc   +1 more source

Mycoplasmas and cancer [PDF]

, 2014
The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan, Liekens, Sandra, Vande Voorde, Johan   +2 more
core  

Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. [PDF]

J Enzyme Inhib Med Chem, 2022
Narczyk M, Wojtyś MI, Leščić Ašler I, Žinić B, Luić M, Jagusztyn-Krynicka EK, Štefanić Z, Bzowska A.   +7 more
europepmc   +1 more source

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source