Results 231 to 240 of about 20,168 (266)

Subacute Toxicity of a Purine Nucleoside Phosphorylase Inhibitor in Rats

Toxicological Sciences, 1995
Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2-week range-finding study where doses of 250 and 500 mg/kg resulted in mortality. In the 4-week study, females given 200 mg/kg were sacrificed during Week 2 due to poor condition. Serum creatinine and urea nitrogen increased 2-
Grushenka H. I. Wolfgang, Hussein Hallak, Ellen Urda, Michael R. Bleavins, O.B. Kasali   +4 more
openaire   +3 more sources

Purine Nucleoside Phosphorylase of Bovine Liver Mitochondria

1991
Purine nucleoside phosphorylase (PNPase, purine nucleoside: orthophosphate ribosyltransferase E.C. 2.4.2.1) in mammals reversibly catalyzes the phosphorolysis of the purine ribonucleosides (deoxy)inosine and (deoxy)guanosine to (deoxy)ribose-l-phosphate and the respective base.
Roger A. Lewis, Robert K. Haag
openaire   +3 more sources

Purine nucleoside phosphorylases: properties, functions, and clinical aspects

Pharmacology & Therapeutics, 2000
The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function. This review updates the properties of the enzymes from eukaryotes and a wide range of prokaryotes, including a tentative ...
David Shugar, David Shugar, Ewa Kulikowska, Agnieszka Bzowska   +3 more
openaire   +3 more sources

A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma

Journal of Clinical Immunology, 2020
B. Al-Saud, Zainab Al Alawi, Faisal Bin Hussain, M. Hershfield, F. Alkuraya, S. Al‐Mayouf   +5 more
semanticscholar   +1 more source

Novel missense mutation in the purine nucleoside phosphorylase gene in a Japanese patient with purine nucleoside phosphorylase deficiency

Pediatrics International, 2002
Takeshi Sakiyama, Misao Owada, Masahiko Tsuda, Kenichi Horinouchi   +3 more
openaire   +3 more sources

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase.

Biochemistry, 2016
G. Isaksen, K. H. Hopmann, J. Åqvist, B. Brandsdal   +3 more
semanticscholar   +1 more source

Development of a new HPLC method using fluorescence detection without derivatization for determining purine nucleoside phosphorylase activity in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016
P. Giuliani, M. Zuccarini, S. Buccella, Margherita Rossini, I. D'alimonte, R. Ciccarelli, M. Marzo, A. Marzo, P. Di Iorio, F. Caciagli   +9 more
semanticscholar   +1 more source

Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori.

International Journal of Biological Macromolecules, 2017
Z. Štefanić, Goran Mikleušević, M. Luić, A. Bzowska, Ivana Leščić Ašler   +4 more
semanticscholar   +1 more source

Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides.

Chemistry, 2015
I. Fateev, Maria I. Kharitonova, K. Antonov, I. Konstantinova, V. Stepanenko, R. Esipov, F. Seela, Kartik W Temburnikar, K. Seley‐Radtke, V. Stepchenko, Yu. A. Sokolov, A. Miroshnikov, I. Mikhailopulo   +12 more
semanticscholar   +1 more source

The dual role of thymidine phosphorylase in cancer development and chemotherapy

Medicinal Research Reviews, 2009
Annelies Bronckaers, Federico Gago
exaly