Results 251 to 260 of about 24,465 (266)

Subacute Toxicity of a Purine Nucleoside Phosphorylase Inhibitor in Rats

Toxicological Sciences, 1995
Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2-week range-finding study where doses of 250 and 500 mg/kg resulted in mortality. In the 4-week study, females given 200 mg/kg were sacrificed during Week 2 due to poor condition. Serum creatinine and urea nitrogen increased 2-
Grushenka H. I. Wolfgang, Hussein Hallak, Ellen Urda, Michael R. Bleavins, O.B. Kasali   +4 more
openaire   +3 more sources

Mycoplasma hyorhinis–Encoded Purine Nucleoside Phosphorylase: Kinetic Properties and Its Effect on the Cytostatic Potential of Purine-Based Anticancer Drugs

Molecular Pharmacology, 2013
A mycoplasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine and 6-aminopurine nucleosides was observed, with adenosine the preferred ...
J. Vande Voorde, S. Liekens, J. Balzarini   +2 more
semanticscholar   +1 more source

Purine Nucleoside Phosphorylase of Bovine Liver Mitochondria

1991
Purine nucleoside phosphorylase (PNPase, purine nucleoside: orthophosphate ribosyltransferase E.C. 2.4.2.1) in mammals reversibly catalyzes the phosphorolysis of the purine ribonucleosides (deoxy)inosine and (deoxy)guanosine to (deoxy)ribose-l-phosphate and the respective base.
Roger A. Lewis, Robert K. Haag
openaire   +3 more sources

Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes

1986
The inherited deficiency of purine nucleoside Phosphorylase results in severe T cell immunodeficiency disease1. We have studied the synthesis of purine nucleoside Phosphorylase during phytohumagglutinin induced T cell transformation and have examined the turnover of purine nucleoside Phosphorylase in the human lymphoblast WI-L2.
Eddie Kwan, Kuldeep Neote, Ellen R. Mably, Floyd F. Snyder   +3 more
openaire   +3 more sources

Novel missense mutation in the purine nucleoside phosphorylase gene in a Japanese patient with purine nucleoside phosphorylase deficiency

Pediatrics International, 2002
Takeshi Sakiyama, Misao Owada, Masahiko Tsuda, Kenichi Horinouchi   +3 more
openaire   +3 more sources

Development of a new HPLC method using fluorescence detection without derivatization for determining purine nucleoside phosphorylase activity in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016
P. Giuliani, M. Zuccarini, S. Buccella, Margherita Rossini, I. D'alimonte, R. Ciccarelli, M. Marzo, A. Marzo, P. Di Iorio, F. Caciagli   +9 more
semanticscholar   +1 more source

Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori.

International Journal of Biological Macromolecules, 2017
Z. Štefanić, Goran Mikleušević, M. Luić, A. Bzowska, Ivana Leščić Ašler   +4 more
semanticscholar   +1 more source

Three-dimensional structure of E. Coli purine nucleoside phosphorylase at 0.99 Å resolution

, 2016
V. Timofeev, Yu. A. Abramchik, N. E. Zhukhlistova, T. Muravieva, R. Esipov, I. Kuranova   +5 more
semanticscholar   +1 more source

Flow‐Synthesis of Nucleosides Catalyzed by an Immobilized Purine Nucleoside Phosphorylase from Aeromonas hydrophila: Integrated Systems of Reaction Control and Product Purification

, 2015
E. Calleri, Giulia Cattaneo, M. Rabuffetti, I. Serra, T. Bavaro, G. Massolini, G. Speranza, D. Ubiali   +7 more
semanticscholar   +1 more source

Purine nucleoside phosphorylase

, 2017
K. Thakur, A. Priyanka
semanticscholar   +1 more source