Results 211 to 220 of about 1,617,490 (298)

Synthetic Routes and Pharmacological Activities of Purine Derivatives: A Review

Current Organic Chemistry, 2023
The Purine moiety is regarded as the ubiquitous nitrogen-containing heterocycle in nature and is recognized as a privileged scaffold in medicinal chemistry.
Youssef Kandri Rodi, El Mokhtar Essassi
exaly   +2 more sources

Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery

Current Topics in Medicinal Chemistry
Numerous purine-containing compounds have undergone extensive investigation for their medical efficacy across various diseases. The swift progress in purine-based medicinal chemistry has brought to light the therapeutic capabilities of purine-derived ...
Neha Rana, Parul Grover, Hridayanand Singh   +2 more
exaly   +2 more sources

Purine derivatives with antituberculosis activity

Russian Chemical Reviews, 2018
The review summarizes the data published over the last 10 – 15 years concerning the key groups of purine derivatives with antituberculosis activity. The structures of purines containing heteroatoms (S, O, N), fragments of heterocycles, amino acids and peptides ...
Dmitry A. Gruzdev, Vera V. Musiyak, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin   +4 more
openaire   +2 more sources

The inhibition mechanism and adsorption behavior of three purine derivatives on the corrosion of copper in alkaline artificial seawater: Structure and performance

, 2021
The inhibition mechanism and adsorption behavior of three purine derivatives (guanine (G), adenine (A), and hypoxanthine (I)) on the corrosion of copper in alkaline artificial seawater were studied by electrochemical tests, scanning electron microscopy ...
Xiaomeng Guo, Hualiang Huang, Dong Liu
semanticscholar   +1 more source

Bio-Inspired Dual Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives.

Journal of Medicinal Chemistry, 2020
In the search for new drug-like selective G-quadruplex binders, a bio-inspired design focused on the use of nucleobases as synthons in a multicomponent reaction has been herein proved to be viable and successful.
Sveva Pelliccia, Jussara Amato, Domenica Capasso, S. Di Gaetano, A. Massarotti, Marialuisa Piccolo, Carlo Irace, G. Tron, Bruno Pagano, A. Randazzo, E. Novellino, Mariateresa Giustiniano   +11 more
semanticscholar   +1 more source

Thiol functionalized carbon ceramic electrode modified with multi-walled carbon nanotubes and gold nanoparticles for simultaneous determination of purine derivatives.

Materials Science and Engineering C: Materials for Biological Applications, 2020
In this proof-of-concept study, a thiol-functionalized sol-gel-based carbon ceramic electrode (CCE) was developed. This CCE was further modified by immobilizing gold nanoparticles (AuNP) in the thiol-functionalized ceramic matrix as well as incorporating
C. Ferrag, M. Noroozifar, K. Kerman
semanticscholar   +1 more source

A PASE Approach to the Synthesis of Benzimidazopurines as Polycondensed Purine Derivatives

Synthesis, 2020
A highly efficient PASE approach to a new class of polycyclic purine derivatives has been proposed. The strategy includes a consecutive reduction, auto-aromatization, and heterocyclization of the initial nitrobenzimidazopyrimidines obtained by a three ...
V. Fedotov, E. Ulomsky, K. Savateev, E. M. Mukhin, D. A. Gazizov, E. Gorbunov, V. Rusinov   +6 more
semanticscholar   +1 more source

Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety

Chinese Chemical Letters, 2018
Baoan Song
exaly   +2 more sources

Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry, 2018
Grazyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk   +2 more
exaly   +2 more sources