Results 221 to 230 of about 1,617,490 (298)

Synthesis of purine derivatives

Pharmaceutical Chemistry Journal, 1967
The methylation of 2-chloro-7-methylhypoxanthine in aqueous alkali forms, as well as 2-chloro-1,7-dimethylhypoxanthine, two isomers of this compound. These isomers were isolated and characterized as 2 chloro-3,7-dimethylhypoxanthine and 2 chloro-6-oxo-7, 9-dimethylpurine betaine.
I. M. Ovcharova, E. S. Golovchinskaya
openaire   +1 more source

Co-exposure degradation of purine derivatives in sulfate radical-mediated oxidation process.

Environmental Science and Technology, 2019
Purines are the most widely occurring heterocyclic-N compounds. The degradation behaviours of purine derivatives, theophylline (TPL) and adenine (ADN) as representatives, in both single-component and mixture systems during UV/peroxydisulfate (PDS ...
Shuangshuang Cheng, Y. Lei, Xin Lei, Yanheng Pan, Yunho Lee, Xin Yang   +5 more
semanticscholar   +1 more source

Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and Clinical Applications

Chemistry and Biodiversity
Caffeine and purine derivatives represent interesting chemical moieties, which show various biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine alkaloids and it is present in food, beverages, and drugs. Coffee, tea,
A. Abu‐Hashem, O. Hakami, Mohamed El-Shazly, H. El-Nashar, M. Yousif   +4 more
semanticscholar   +1 more source

New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia.

Bioorganic chemistry (Print), 2019
Bcr-Abl and Btk kinases are among the targets that have been considered for the treatment of leukemia. Therefore, several strategies have focused on the use of inhibitors as chemotherapeutic tools to treat these types of leukemia, such as imatinib (for ...
J. Bertrand, H. Dostálová, V. Kryštof, Radek Jorda, A. Castro, J. Mella, C. Espinosa-Bustos, Ana María Zarate, C. Salas   +8 more
semanticscholar   +1 more source

Density functional study on the derivatives of purine

Journal of Molecular Modeling, 2012
The derivatives of purine are designed through substituting the hydrogen atoms on it for nitro and amino functional groups. Geometries and frequency are analyzed at the B3LYP/6-31 G** level of density functional theory(DFT). Heats of formation (HOF), bond dissociation energy(BDE) and detonation parameters (detonation velocity and detonation pressure ...
Chi, Wei-Jie, Li, Lu-Lin, Li, Bu-Tong, Wu, Hai-Shun   +3 more
openaire   +2 more sources

Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3.

European journal of medicinal chemistry, 2019
Sustained activation of STAT3 is closely related to the cancer development, but the inhibitors for STAT3 overexpression are still in the clinical research stage.
Xuebao. Wang, Qin He, Kaiqi Wu, Taoning Guo, Xuze Du, Huan Zhang, Longcheng Fang, Nan Zheng, Qihong Zhang, Faqing Ye   +9 more
semanticscholar   +1 more source

Rhodium(ii)-catalyzed annulation of N-sulfonyl-1,2,3-triazoles with 1,3,5-triazinanes to produce octahydro-1H-purine derivatives: a combined experimental and computational study.

Chemical Communications, 2019
The Rh(ii)-catalyzed annulation of N-sulfonyl-1,2,3-triazoles with 1,3,5-triazinanes leading to the octahydro-1H-purine derivatives with moderate to good yields is described in this communication. Mechanistic studies via DFT calculations suggest that the
Jin Ge, Xueli Wu, Xiaoguang Bao
semanticscholar   +1 more source

Effect of dietary energy on digestibilities, rumen fermentation, urinary purine derivatives and serum metabolites in Tibetan and small-tailed Han sheep.

Journal of animal physiology and animal nutrition, 2019
Tibetan sheep are indigenous to the Qinghai-Tibetan Plateau, graze the grassland all year round without supplementation and are well-adapted to the harsh conditions. Small-tailed Han sheep were introduced to the plateau and are raised mainly in feedlots.
Jianwei Zhou, Wenji Wang, X. Jing, A. Degen, Yamin Guo, Jingpeng Kang, Z. Shang, Zhongxiang Yu, Q. Qiu, Xusheng Guo, L. Ding, Guo Yang, R. Long   +12 more
semanticscholar   +1 more source

Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine

Sensors and Actuators B: Chemical, 2018
Gold nanoparticles (AuNPs) is an important kind of nanozymes and a variety of its artificial enzymatic activities have been reported, such as oxidase, peroxidase, and superoxide dismutase.
Yehui Wu, Yuzhi Chen, Yawen Li, Jia Huang, Haoyu Yu, Zhuo Wang   +5 more
semanticscholar   +1 more source

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.

European journal of medicinal chemistry, 2020
This study reports the design, synthesis and evaluation of a series of histone deacetylase (HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2-aminophenyl)-benzamide unit.
Kunal Nepali, Ting-Yu Chang, Mei-Jung Lai, K. Hsu, Y. Yen, T. Lin, Sung-Bau Lee, J. Liou   +7 more
semanticscholar   +1 more source