Results 231 to 240 of about 1,617,490 (298)

Effect of level of oat hay intake on apparent digestibility, rumen fermentation and urinary purine derivatives in Tibetan and fine-wool sheep

Animal Feed Science and Technology, 2018
Tibetan sheep are indigenous to the Qinghai-Tibetan Plateau and are raised at an altitude between 3000–5000 m. In contrast, the crossbred fine-wool sheep were introduced to the plateau and are raised at an altitude between 2600 to 3500 m.
J. W. Zhou, X. Jing, A. Degen, H. Liu, Yafei Zhang, G. Yang, R. Long   +6 more
semanticscholar   +1 more source

Design and Synthesis of Purine Connected Piperazine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis.

Bioorganic & Medicinal Chemistry Letters, 2020
A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculosis. The compounds were designed to target MurB disrupting the biosynthesis of the peptidoglycan and exert ...
Srihari Konduri, J. Prashanth, V. Krishna, D. Sriram, J. Behera, D. Siegel, Koya Prabhakara Rao   +6 more
semanticscholar   +1 more source

Syntheses in a series of purine derivatives

Pharmaceutical Chemistry Journal, 1967
From 2-chloro-1,7-dimethylhypoxanthine are synthesized 1,7-dimethylhypoxanthine-2-acetic acid, certain of its derivatives, and also a series of derivatives of 1,7-dimethylhypoxanthine substituted at C2, among them 2-diethylaminomethyl-1,7-dimethylhypoxanthine andβ-(1,7-dimethylhypoxanthine-2)α-alanine.
I. M. Ovcharova, L. N. Babenko, E. S. Golovchinskaya   +2 more
openaire   +1 more source

The dye-sensitized photooxidation of purine and pyrimidine derivatives

Archives of Biochemistry and Biophysics, 1964
Abstract In the presence of light and methylene blue (MB), a reaction leading to the loss of ultraviolet absorbance accompanied by the uptake of 1 mole O 2 per mole substrate occurs with guanine derivatives. The wavelengths of light that are most effective are those that are absorbed by the sensitizer; MB acts in a catalytic fashion i.e., it is not ...
M I, SIMON, H, VANVUNAKIS
openaire   +2 more sources

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

Antiviral Research, 1987
Various 3-hydroxy-2-phosphonylmethoxypropyl (HPMP) and 2-phosphonylmethoxyethyl (PME) derivatives of purine [adenine (A), guanine (G), 2,6-diaminopurine (DAP), 2-monoaminopurine (MAP), hypoxanthine (HX)] and pyrimidine [cytosine (C), uracil (U), thymine (T)] have been evaluated for their antiviral properties.
E, De Clercq, T, Sakuma, M, Baba, R, Pauwels, J, Balzarini, I, Rosenberg, A, Holý   +6 more
openaire   +2 more sources

Antiviral properties and interaction of novel chalcone derivatives containing a purine and benzenesulfonamide moiety.

Bioorganic & Medicinal Chemistry Letters, 2018
A new concise and facile method was explored to synthesize a series of novel chalcone derivatives containing a purine and benzenesulfonamide moiety and their antiviral properties were evaluated against TMV and CMV.
Dagui Zhou, D. Xie, Fangcheng He, B. Song, D. Hu   +4 more
semanticscholar   +1 more source

Raphanatin, an unusual purine derivative and a metabolite of zeatin

Biochemical and Biophysical Research Communications, 1972
Abstract When zeatin was supplied to radish seedlings with roots excised, a number of metabolites were formed. These included adenine, adenosine, adenosine 5′-phosphate, zeatin riboside and zeatin riboside 5′-phosphate. However the major metabolite was a glucoside of zeatin which differed from 9-β-D-glucopyranosylzeatin.
C W, Parker, D S, Letham, D E, Cowley, J K, MacLeod   +3 more
openaire   +2 more sources

Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives

Annalen der Pharmacie, 2021
Kristaps Leškovskis, J. Zakis, I. Novosjolova, M. Turks   +3 more
semanticscholar   +1 more source

Effects of purine derivatives on calcitriol metabolism in rats

American Journal of Physiology-Renal Physiology, 1991
The effects of theophylline and sodium urate on metabolic production (PR) and clearance rate (MCR) of calcitriol were determined by the constant isotope infusion method in normal rats. Calcitriol PR was significantly reduced after infusion for 20 h of either theophylline (1 mg/h, PR = 22.3 +/- 1.6 ng.kg-1.day-1, P less than 0.001, n = 5) or sodium ...
C H, Hsu, S R, Patel, E W, Young, R, Vanholder   +3 more
openaire   +2 more sources

Purine derivatives as potent γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2010
The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-based gamma-secretase modulators with 300- to 2000-fold in vitro selectivity over inhibition of Notch ...
Alexey, Rivkin, Sean P, Ahearn, Stephanie M, Chichetti, Christopher L, Hamblett, Yudith, Garcia, Michelle, Martinez, Jed L, Hubbs, Michael H, Reutershan, Matthew H, Daniels, Phieng, Siliphaivanh, Karin M, Otte, Chaomin, Li, Andrew, Rosenau, Laura M, Surdi, Joon, Jung, Bethany L, Hughes, Jamie L, Crispino, George N, Nikov, Richard E, Middleton, Christopher M, Moxham, Alexander A, Szewczak, Sanjiv, Shah, Lily Y, Moy, Candia M, Kenific, Flobert, Tanga, Jonathan C, Cruz, Paula, Andrade, Minilik H, Angagaw, Nirah H, Shomer, Thomas, Miller, Benito, Munoz, Mark S, Shearman   +31 more
openaire   +2 more sources