Results 241 to 250 of about 58,940 (303)

Design, synthesis and biological evaluation of 2,5-diaryloxazolo[4,5-<i>d</i>]pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells. [PDF]

Beilstein J Org Chem
Kachaeva MV, Olejniczak AB, Denel-Bobrowska M, Zhirnov VV, Velihina YS, Pilyo SG, Brovarets VS.   +6 more
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Evaluation of the Antimicrobial Potential of Malaysian Kelulut Honeydew Honey Against Acne Pathogens. [PDF]

Curr Microbiol
Chin SW, Azman AS, Yap MKK, Tan JW.
europepmc   +1 more source

Blood Coagulation Activity of Purine Derivatives

The Journal of Kansai Medical University, 1958
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Microbiota-Driven Metabolic Alterations Induced by BPA, TDCPP and PFOA in an Ex Vivo Human Fecal Fermentation Model. [PDF]

Chem Res Toxicol
Sabuz O, Folz J, Deepika D, Blanco J, Schuhmacher M, Aichinger G, Kumar V.   +6 more
europepmc   +1 more source

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Synthesis of purine derivatives

Pharmaceutical Chemistry Journal, 1967
The methylation of 2-chloro-7-methylhypoxanthine in aqueous alkali forms, as well as 2-chloro-1,7-dimethylhypoxanthine, two isomers of this compound. These isomers were isolated and characterized as 2 chloro-3,7-dimethylhypoxanthine and 2 chloro-6-oxo-7, 9-dimethylpurine betaine.
I. M. Ovcharova, E. S. Golovchinskaya
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Purine derivatives with antituberculosis activity

Russian Chemical Reviews, 2018
The review summarizes the data published over the last 10 – 15 years concerning the key groups of purine derivatives with antituberculosis activity. The structures of purines containing heteroatoms (S, O, N), fragments of heterocycles, amino acids and peptides ...
Dmitry A. Gruzdev, Vera V. Musiyak, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin   +4 more
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Purine derivatives as potent γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2010
The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-based gamma-secretase modulators with 300- to 2000-fold in vitro selectivity over inhibition of Notch ...
Alexey, Rivkin, Sean P, Ahearn, Stephanie M, Chichetti, Christopher L, Hamblett, Yudith, Garcia, Michelle, Martinez, Jed L, Hubbs, Michael H, Reutershan, Matthew H, Daniels, Phieng, Siliphaivanh, Karin M, Otte, Chaomin, Li, Andrew, Rosenau, Laura M, Surdi, Joon, Jung, Bethany L, Hughes, Jamie L, Crispino, George N, Nikov, Richard E, Middleton, Christopher M, Moxham, Alexander A, Szewczak, Sanjiv, Shah, Lily Y, Moy, Candia M, Kenific, Flobert, Tanga, Jonathan C, Cruz, Paula, Andrade, Minilik H, Angagaw, Nirah H, Shomer, Thomas, Miller, Benito, Munoz, Mark S, Shearman   +31 more
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Strukturanaloga der natürlichen Purin‐Derivate

Angewandte Chemie, 1961
AbstractDie Synthese von purin‐ähnlichen biheterocyclischen Ringsystemen wird beschrieben und insbesondere der Aufbau von verschieden substituierten Pyrazolo[3.4‐d] pyrimidinen ausgehend von Pyrazolen oder Pyrimidinen besprochen. Synthesewege für Pyrazolo[3.4‐c] pyridazine und Pyrazolo[3.4‐b] pyridine ausgehend von Pyridazinen und Pyridinen und von ...
Paul Schmidt, K. Eichenberger, M. Wilhelm   +2 more
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Heterocyclic derivatives of purines. 5. Nucleophilic substitution in series of imidazo[1,2-f]purine derivatives

Chemistry of Heterocyclic Compounds, 1984
The chlorination of 1,8-dimethyl-7-phenylimidazo[1,2-f]xanthine with an equimolar amount of PCl5 in POCl3 leads to 2,4-dichloro-8-methyl-7-phenylimidazo[1,2-f]-purine. The possibility of substitution of the halogen atoms in reactions with nucleophilic reagents to give various 4-amino and 2,4-diamino derivatives was studied.
S. N. Garmash, B. A. Priimenko, N. A. Klyuev, N. I. Romanenko, A. K. Sheinkman   +4 more
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