Results 101 to 110 of about 1,297,457 (342)

Fibroblast growth factor 2 modulates extracellular purine metabolism by upregulating ecto-5′-nucleotidase and adenosine deaminase in cultured rat spinal cord astrocytes

Journal of Pharmacological Sciences, 2019
Purinergic signaling via ATP and adenosine produced by astrocytes is one pathway underlying neuron–glia interactions in the central nervous system (CNS). In production of purines, extracellular metabolism of released purines via ecto-enzymes is important.
Ryota Eguchi, Soichiro Yamaguchi, Ken-ichi Otsuguro   +2 more
doaj   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis

Frontiers in Microbiology
IntroductionAtopic dermatitis (AD) is one of the most common inflammatory skin diseases. Skin microecological imbalance is an important factor in the pathogenesis of AD, but the underlying mechanism of its interaction with humans remains unclear ...
Kaikai Huang, Fang Li, Yingyao Liu, Baoying Liang, Pinghua Qu, Linlin Yang, Shanshan Han, Wenjun Li, Xiumei Mo, Xiumei Mo, Xiumei Mo, Lei Dong, Ying Lin, Ying Lin, Ying Lin   +14 more
doaj   +1 more source

Purine Metabolism in Toxoplasma gondii

Journal of Biological Chemistry, 1989
We have studied the incorporation and interconversion of purines into nucleotides by freshly isolated Toxoplasma gondii. They did not synthesize nucleotides from formate, glycine, or serine. The purine bases hypoxanthine, xanthine, guanine, and adenine were incorporated at 9.2, 6.2, 5.1, and 4.3 pmol/10(7) cells/h, respectively.
Randolph L. Berens, Edward C. Krug, J. Joseph Marr   +2 more
openaire   +3 more sources

Purine metabolism in the development of osteoporosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Keda Yang, Jie Li, Lin Tao
semanticscholar   +1 more source

Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington's Disease Mouse Model

Frontiers in Physiology, 2017
Huntington's disease (HD) is a fatal neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (HTT). HD has a peripheral component to its pathology: skeletal muscles are severely affected, leading to atrophy, and ...
M. Mielcarek, R. Smolenski, M. Isalan
semanticscholar   +1 more source

The Origin of the Feedstock Molecules for Life on the Hadean Earth

Angewandte Chemie International Edition, EarlyView.
The origin of life in the Hadean eon required the formation of amino acids and nucleosides among the key molecules of life. In an often postulated strongly reducing atmosphere, HCN and its derivatives are robustly formed as plausible starting molecules. But HCN does not form in a Hadean, weakly reducing atmosphere.
Nikolai Diukarev, Erik Boinowitz, Jonas Feldmann, Stefan Wiedemann, Aleksandr Mikheev, Sidney Becker, Thomas Carell   +6 more
wiley   +1 more source

Metabolic Profiling of Non-volatile Compounds during Xinyang Maojian Tea Processing Using Untargeted Metabolomics [PDF]

Shipin Kexue
In order to understand the dynamic changes of non-volatile metabolites in Xinyang Maojian tea during processing, Xinyang Maojian tea samples from Xinyang tea population (Camellia sinensis cv.
KONG Yashuai, CHEN Lingzhi, CHENG En, ZHU Yao, WANG Jingjing, WANG Xiao, WANG Zihao, CHEN Yi, YIN Peng, GUO Guiyi
doaj   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source

A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders.

Investigative Ophthalmology and Visual Science, 2018
Purpose Dominant optic atrophy (DOA; MIM [Mendelian Inheritance in Man] 165500), resulting in retinal ganglion cell degeneration, is mainly caused by mutations in the optic atrophy 1 (OPA1) gene, which encodes a dynamin guanosine triphosphate (GTP)ase ...
C. Bocca, J. Kouassi Nzoughet, S. Leruez, P. Amati‐Bonneau, M. Ferré, M. Kane, C. Veyrat-Durebex, J. M. Chao De La Barca, A. Chevrollier, C. Homedan, C. Verny, D. Milea, V. Procaccio, G. Simard, D. Bonneau, G. Lenaers, P. Reynier   +16 more
semanticscholar   +1 more source