Results 91 to 100 of about 971,178 (247)

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen
Bacterial pathogens rely on the constant availability of purine and pyrimidine nucleotides to facilitate replication, growth, and virulence and to sustain energy metabolism and nucleotide‐based signaling.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
doaj   +1 more source

Factors Influencing Muscle Purine Nucleotide Metabolism.

, 2006
The experiments in this thesis were designed to investigate the factors influencing the metabolism of purine nucleotides in human skeletal muscle, plasma and urine.
Stathis, Christos
core  

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the ...
Geetha Bhagavatula, J. Scott Lee, Sean P. Colgan, Rachael E. Kostelecky, Liheng Zhou, Corey S. Worledge   +5 more
core   +1 more source

Differential metabolic responses of mouse Leydig and spermatogonia cells to radiofrequency electromagnetic field exposure

Frontiers in Public Health
IntroductionAlthough existing studies have shown that radiofrequency electromagnetic fields (RF-EMFs) have a variety of effects on living organisms, the specific impact of RF-EMFs on the metabolism of reproductive cells and their underlying mechanisms ...
Xia Miao, Xia Miao, Yanyun Lin, Juan Guo, Jiajin Lin, Peng Gao, Wei Zhang, Lihua Zeng, Guozhen Guo, Guozhen Guo, Jing Li, Jing Li   +11 more
doaj   +1 more source

Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose

Redox Biology, 2016
Complex metabolism is thought to occur exclusively in the crowded intracellular environment. Here we report that diluted enzymes from lysed human leukocytes produce extracellular energy.
John B. Hibbs Jr., Zdenek Vavrin, James E. Cox   +2 more
doaj   +1 more source

Human Purine Metabolism and Behavior

, 1970
One genetic disease of human metabolism, which results in degradation of mental and neurological functions, has been traced to inactivity of the enzyme ...
Nyhan, William L.
core  

In Vitro and In Vivo Evaluation of Pediococcus acidilactici Pedio6-1 for Purine Metabolism Modulation in Diet-Induced Obese Mice

Microorganisms
Gut lactic acid bacteria are emerging as potential targets for modulating host purine metabolism and alleviating hyperuricemia-related disorders. This study aimed to isolate purine-degrading lactic acid bacterial strains from porcine intestine and ...
Haohua Fu, Hengjia Ni, Jianhui Wang, Tuo Leng, Shusong Wu, Pan Huang, Jianjun Li, Cimin Long, Yulong Yin   +8 more
doaj   +1 more source

Purine metabolism in Echinococcus multilocularis

, 1998
International audienceThe activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its ...
Suchail, S, Sarciron, M,, Petavy, A,, S Suchail, M.E Sarciron, A.F Petavy   +5 more
core   +2 more sources

Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis

Frontiers in Microbiology
IntroductionAtopic dermatitis (AD) is one of the most common inflammatory skin diseases. Skin microecological imbalance is an important factor in the pathogenesis of AD, but the underlying mechanism of its interaction with humans remains unclear ...
Kaikai Huang, Fang Li, Yingyao Liu, Baoying Liang, Pinghua Qu, Linlin Yang, Shanshan Han, Wenjun Li, Xiumei Mo, Xiumei Mo, Xiumei Mo, Lei Dong, Ying Lin, Ying Lin, Ying Lin   +14 more
doaj   +1 more source