Results 91 to 100 of about 1,020,918 (293)

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Advanced Science
Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, and cognitive impairments.
Ben Lin, Zhen Ye, Zhan Cao, Zhao Ye, Yifei Yu, Weiliang Jiang, Sichen Guo, Vladimir Melnikov, Peng Zhou, Chenxing Ji, Chengzhang Shi, Zerui Wu, Zhengyuan Chen, Yihua Xu, Qilin Zhang, Zengyi Ma, Nidan Qiao, Long Chen, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Li Zhang, Min He, Yongfei Wang, Hongying Ye, Yiming Li, Zhaoyun Zhang, Meng Wang, Renyuan Gao, Yichao Zhang   +29 more
doaj   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis

Cell Death and Disease
Osteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay ...
Keda Yang, Xiaochuan Wang, Chi Zhang, Dian Liu, Lin Tao   +4 more
doaj   +1 more source

Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle.

PLoS Computational Biology, 2015
Metabolism is the major output of the circadian clock in many organisms. We developed a computational method to integrate both circadian gene expression and metabolic network.
Ying Li, Guang Li, Benjamin Görling, Burkhard Luy, Jiulin Du, Jun Yan   +5 more
doaj   +1 more source

Morphogenesis of cardiomyopathy under disorders of purine metabolism

, 2002
Morphofunctional changes of myocard during modelling of disorders of purine metabolism were studied. It was demon­strated that disorders of purine metabolism is cause of productive endocarditis and interstitial ...
Боднар, Р. Я.
core  

Purine metabolism in Echinococcus multilocularis

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1998
The activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its purine requirement. Therefore, these enzymes may be targets for drugs in the chemotherapeutic treatment of diseases caused by ...
Suchail, S, Sarciron, M, Petavy, A
openaire   +3 more sources

Evolutionary accumulation of protein domains at FF level of structural abstraction in the central pathways of purine metabolism.

, 2013
Evolutionary accumulation of protein domains at FF level of structural abstraction in the central pathways of purine metabolism.
Gustavo Caetano-Anollés (65405), Kelsey Caetano-Anollés (389000)   +1 more
core   +1 more source

Effects of cocoa on altered metabolite levels in purine metabolism pathways and urea cycle in Alzheimer's disease in C. elegans

, 2022
Effects of cocoa on altered metabolite levels in purine metabolism pathways and urea cycle in Alzheimer's disease in C ...
R Afshari (7761815), Dan Dias (14681695), A Almotayri (14654006), D Heydarian (14654003), J Thomas (6980678), M Jois (13289826), M Munasinghe (13297410)   +6 more
core  

Purine Metabolism changes in response to liver irradiation.

, 2015
A general increase in purine metabolism intermediates may suggest increased breakdown of nucleotides in response to radiation perhaps as a mechanism to support repair after cell injury.
Laibin Liu (161095), Robert Mohney (210019), Pilib Ó. Broin (749963), Aaron Golden (55908), Chandan Guha (161116), Gang Su (29558), Irwin Jack Kurland (749962), Fan Meng (60551), Shilpa Kulkarni (749964)   +8 more
core   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen
Bacterial pathogens rely on the constant availability of purine and pyrimidine nucleotides to facilitate replication, growth, and virulence and to sustain energy metabolism and nucleotide‐based signaling.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
doaj   +1 more source