Results 101 to 110 of about 1,020,918 (293)

[Purine metabolism in human tumors].

, 1989
Levels of oxypurines (hypoxanthine and xanthine) and uric acid were measured in plasma and urine of tumor bearing patients (gastric and colon rectal tumors), and of subjects affected by non specific diseases.
R. Caldarone, D. Vannoni, B. Porcelli, GARZI, Alfredo   +3 more
core  

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Differential metabolic responses of mouse Leydig and spermatogonia cells to radiofrequency electromagnetic field exposure

Frontiers in Public Health
IntroductionAlthough existing studies have shown that radiofrequency electromagnetic fields (RF-EMFs) have a variety of effects on living organisms, the specific impact of RF-EMFs on the metabolism of reproductive cells and their underlying mechanisms ...
Xia Miao, Xia Miao, Yanyun Lin, Juan Guo, Jiajin Lin, Peng Gao, Wei Zhang, Lihua Zeng, Guozhen Guo, Guozhen Guo, Jing Li, Jing Li   +11 more
doaj   +1 more source

Treatment‐Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C. Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

Purine metabolism dysregulation as a multi-omics signature of fatal Candida auris infection

Mycology
Candida auris is a multidrug-resistant fungal pathogen linked to global healthcare outbreaks. Its metabolic processes affecting disease severity and patient outcomes are not well understood. We conducted a multi-omics analysis of 44 clinical C.
Mohammad T. Al Bataineh, Andre S. Barreiros, Sreejisha P. Sreedharan, Nihar R. Dash, Savitha Mudalagiriyappa, Noura Alkhayyal, Basem Al-Omari, Halima Alnaqbi   +7 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Multi-omics analysis of the individual and combined effects of long-term sleep deprivation and a high-fat diet on lung injury

European Journal of Medical Research
Background Chronic sleep deprivation (SD) from shift work and a high-fat diet (HFD) disrupt circadian rhythms and affect physiological systems, yet their impact on lung circadian rhythms remains poorly understood.
Min Zhu, Xuehan Yuan, Zihuan Hu, Yihan Gao, Yuqin Wu, Chang Chen, Peng Duan, Junwen Chen   +7 more
doaj   +1 more source