Results 161 to 170 of about 61,638 (306)

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

An integrated bioinformatics and machine learning approach to identifying biomarkers connecting parkinson's disease with purine metabolism-related genes. [PDF]

BMC Neurol
Wang Y, Wu D, Zheng M, Yang T.
europepmc   +1 more source

cdh23 affects congenital hearing loss through regulating purine metabolism. [PDF]

Front Mol Neurosci, 2023
Yang S, Xie BL, Dong XP, Wang LX, Zhu GH, Wang T, Wu WJ, Lai RS, Tao R, Guan MX, Chen FY, Tan DH, Deng Z, Xie HP, Zeng Y, Xiao ZA, Xie DH.   +16 more
europepmc   +1 more source

Relation between coronary artery stenosis and myocardial purine metabolism, histology and regional function in humans

, 1987
Willem Flameng, Johan Vanhaecke, Herman Van Belle, Μ. Borgers, L de Beer, J. Minten   +5 more
openalex   +1 more source

Opioid use affects antioxidant activity and purine metabolism: preliminary results [PDF]

, 2009
Paolo Mannelli, Ashwin A. Patkar, Steve Rozen, Wayne R. Matson, Ranga Krishnan, Rima Kaddurah‐Daouk   +5 more
openalex   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

Multi-Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide-Induced Mouse Model of Depression. [PDF]

Brain Behav
Li WW, Xiao R, Chen XY, Pu JC, Chen JJ, Wang HY, Liu LX, Li D, Zhang YD, Li WX, Xie P.   +10 more
europepmc   +1 more source

Assessing gout risk associated with GLP‐1 therapy in obese patients with type 2 diabetes: A retrospective cohort study

Rheumatology &Autoimmunity, EarlyView.
Justin Riley Lam, Emmanuel Otabor, Laith Alomari, Maxim Barnett, Bal Subedi, Het Hirpara, Freya Thummar   +6 more
wiley   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

British Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia, Andrea Pastor‐Martínez, Céline Decouty‐Pérez, Ana Belen Lopez‐Rodriguez, María Álvarez‐Rubal, Eva Ramos, Francesco Calzaferri, Jorge Zamorano‐Fernández, Javier Giner‐García, Alexis J. Palpán‐Flores, Víctor Rodríguez‐Domínguez, Javier Rodríguez de Cía, Borja J. Hernández‐García, Alejandro Romero, Cristóbal de los Ríos, Javier Egea   +15 more
wiley   +1 more source

Ultrasound irradiation activates purine metabolism and mitochondrial respiration via the MAPK signaling pathway in myotubes. [PDF]

Biochem Biophys Rep
Ma X, Maeshige N, Yamaguchi A, Fu Y, Xing J, Guo Q, Lin H, Lu F, Kondo H, Fujino H.   +9 more
europepmc   +1 more source