Results 181 to 190 of about 1,551,682 (283)

Increased Generation of Hypoxanthine: How Adaptation of Purine Metabolism Drives Vascular Remodeling in Pulmonary Hypertension. [PDF]

JACC Basic Transl Sci
Schäfer K.
europepmc   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Purine Metabolism Pathway Influence on Running Capacity in Rats. [PDF]

Metabolites
Chen D, Biney CN, Wang Q, Cai M, Cheng S, Chen W, Zhang J, Zhao J, Zhang Y, Zhang W.   +9 more
europepmc   +1 more source

PURINE METABOLISM

Journal of Biological Chemistry, 1930
openaire   +1 more source

Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi, Jaejun Heo, Sungho Won, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Juhee Ahn, Soo Wan Kim   +7 more
wiley   +1 more source

Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN. [PDF]

Cancer Med
Jiang Y, Xiao H, Yang Y, Chen G, Zhang Y, Wu X, Zhang Q, Huang Q, Gao H, Han Y, Zhang A, Jiang D, Zheng L, Li Y, Gao Y.   +14 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment. [PDF]

Cell Death Dis
D'Aprile S, Denaro S, Torrisi F, Longhitano L, Giallongo S, Giallongo C, Bontempi V, Bucolo C, Drago F, Mione MC, Li Volti G, Potokar M, Jorgačevski J, Zorec R, Tibullo D, Amorini AM, Vicario N, Parenti R.   +17 more
europepmc   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

<i>Fusobacterium nucleatum</i> plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [PDF]

Gut Microbes
Hou S, Ning T, Liu S, Yang X, Ye H, Zhou Y, Wang C, Zhu J, Lu S, Zhang N, Zhu S.   +10 more
europepmc   +1 more source