Results 191 to 200 of about 1,020,918 (293)

Distinct Immunometabolic Profiles in Finnish and Russian Karelian Adolescents With Contrasting Allergy Risk

Allergy, EarlyView.
We compared Finnish and Russian Karelian adolescents with contrasting allergy burden using integrated proteomic, metabolomic, and transcriptomic profiling. Finnish adolescents showed a broader pro‐inflammatory PBMC secretory profile consistent with a low‐grade inflammatory phenotype.
Nanna Fyhrquist, Matilda Riskumäki, Piia Karisola, Anni Nieminen, Tiina Laatikainen, Hanna Sinkko, Laura Paalanen, Pekka Jousilahti, Erkki Vartiainen, Mika J. Mäkelä, Tari Haahtela, Harri Alenius   +11 more
wiley   +1 more source

Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction. [PDF]

BMC Microbiol
Ru Y, Yu Y, Liu C, Liu Y, Liu D, Chen R, Chen X, Bai X, Jiang T, Duan J.   +9 more
europepmc   +1 more source

DISORDERS OF PURINE AND PYRIMIDINE METABOLISM

Purine and pyrimidine metabolism represents one of the most essential and tightly regulated biochemical pathways in living organisms, as it ensures the balanced synthesis and degradation of nucleotides required for cellular growth, differentiation, and ...
Kubayev Jo‘rabek Eshmamatovich, Firuza Farxodovna Ibragimova, Normurodov Xushid Tursunmurodovich, Raubjonov Xusanboy Mamatolibovich   +3 more
core  

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT. [PDF]

Science
Wu Z, Nguyen PT, Sondhi V, Yao RW, Lu Z, Dai T, Chiang JC, Cai F, Williams IM, Blatt EB, Shang Z, Cai L, Zhang J, Moore MD, Alshamleh I, Li X, Ogu T, Zacharias LG, Winston R, Patricio JS, Johnson X, Chen WM, Cong Q, Mathews TP, Zhang Y, Zhang L, DeBerardinis RJ.   +26 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings. [PDF]

Anim Nutr
Li X, Xie Y, Zhang M, Zou T, Zhong C, Rajput ZI, Bi S, Cao L.   +7 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

2,6-Diazidopurine Nucleosides as Useful Intermediates for the Synthesis of Novel Triazolyl Purine Analogs

Purine nucleosides, 2,6-diazidopurine nucleosides, 2,6-bis-triazolyl purine derivatives, 1,3-dipolar cycloaddition, nucleophilic aromatic ...
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source