Results 191 to 200 of about 1,551,682 (283)

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

AI‐Assisted Literature Mining Reveals Spatiotemporal Heterogeneity and Progression Trajectories of Traditional Chinese Medicine Syndromes in Coronary Heart Disease in China

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Despite the centrality of syndrome differentiation in guiding personalized traditional Chinese medicine (TCM) interventions for coronary heart disease (CHD), existing studies of TCM syndrome distribution are constrained by fragmented methodologies and limited spatiotemporal resolution. In this study, we employed an artificial intelligence (AI)‐
Qianzi Che, Tian Song, Zhaoyuan Gong, Chuxuan Wang, Bin Liu, Mingzhi Hu, Ning Liang, Haili Zhang, Huizhen Li, Qingyang Zeng, Lin Chen, Yuanming Leng, Xihao Cao, Jing Wan, Jing Guo, Nannan Shi   +15 more
wiley   +1 more source

Synergistic Probiotic-Postbiotic Therapy Ameliorates Hyperuricemia via Multi-Target Regulation of Purine Metabolism and Gut Microbiota. [PDF]

Foods
Ren L, Liu S, Wang S, Li Z, Lu F, Luo X.
europepmc   +1 more source

Evaluation of Torula Yeast (Candida utilis) Single Cell Proteins as a Partial Replacement for Soybean Meal in Broiler Diets: Effects on Productive Performance, Meat Quality Traits, and Plasma Metabolome

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Over recent years the use of yeast in feedstuffs has gained momentum due to novel developments in single‐cell proteins (SCPs). SCPs are considered a sustainable protein source, as their production enable to convert low‐value substrates (including industrial/agricultural wastes) into feed, with a related reduced environmental impact. This study
Jonathan Dayan, Marco Zampiga, Francesca Soglia, Luca Laghi, Elisa Benini, Massimiliano Petracci, Federico Sirri   +6 more
wiley   +1 more source

Purine metabolism-associated key genes depict the immune landscape in gout patients. [PDF]

Discov Oncol
Li LN, Wang H, Xiao LS, Lai WN.
europepmc   +1 more source

L‐Glutamine Plus L‐Glutamic Acid Enhances Antioxidant Status and Ammonia Toxicity Resilience, Upregulates Interleukin IL‐10 Gene, and Improves Gut Microbiota and Survival in Juvenile Nile Tilapia

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Glutamine (Gln) and glutamic acid (Glu) are the most abundant free amino acids (AAs) in the fish body. Although classified as non‐essential AAs, their supplementation can be a strategy to optimize the growth performance and health of fish.
Cristiana Leonor da Silva Carneiro, Thaís Pereira da Cruz, Larissa Cassemiro Pacheco Monteiro, Larissa Glugoski, Mariana Vieira Feldhaus, Leandro Cavalcante Lipinski, Marcelo Ricardo Vicari, Viviane Nogaroto, Valéria Rossetto Barriviera, Wilson Massamitu Furuya   +9 more
wiley   +1 more source

An integrated bioinformatics and machine learning approach to identifying biomarkers connecting parkinson's disease with purine metabolism-related genes. [PDF]

BMC Neurol
Wang Y, Wu D, Zheng M, Yang T.
europepmc   +1 more source

Natural variation in OsMYB305 downregulating cytokinin‐mediated inhibition of leaf senescence contributes to regional adaptation in rice

New Phytologist, EarlyView.
Proposed regulatory model of OsMYB305 in leaf senescence. Summary Accumulating evidence has identified transcription factors (TFs) as key regulators of the onset and progression of leaf senescence. However, the regulatory role of the rice myeloblastosis (MYB) TF OsMYB305 in this process remains largely unknown.
Boyeong Kim, Jinah Kim, Yejin Shim, Jinku Kang, Hyeryung Yoon, Sung‐Hwan Cho, Nam‐Chon Paek, Kiyoon Kang   +7 more
wiley   +1 more source

Resensitizing β-Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment. [PDF]

Adv Sci (Weinh)
Shi T, Wu Q, Ruan Z, Luo Z, Wang W, Guo Z, Ma Y, Wang X, Chu G, Lin H, Ge M, Chen Y.   +11 more
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source