Results 211 to 220 of about 971,178 (247)

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Lnc-TPT1-AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression. [PDF]

Cancer Sci
Zhang Y, Zhang H, Li M, Li Y, Wang ZR, Cheng W, Liu Y, Fang Z, Zheng A, Wang J, Ma F.   +10 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16. [PDF]

FEBS J
Feng M, Gao B, Garcia LR, Sun Q.
europepmc   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E. [PDF]

Front Immunol
Zhang J, Zhang X, Wu R, Dong CS.
europepmc   +1 more source

AI‐Assisted Literature Mining Reveals Spatiotemporal Heterogeneity and Progression Trajectories of Traditional Chinese Medicine Syndromes in Coronary Heart Disease in China

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Despite the centrality of syndrome differentiation in guiding personalized traditional Chinese medicine (TCM) interventions for coronary heart disease (CHD), existing studies of TCM syndrome distribution are constrained by fragmented methodologies and limited spatiotemporal resolution. In this study, we employed an artificial intelligence (AI)‐
Qianzi Che, Tian Song, Zhaoyuan Gong, Chuxuan Wang, Bin Liu, Mingzhi Hu, Ning Liang, Haili Zhang, Huizhen Li, Qingyang Zeng, Lin Chen, Yuanming Leng, Xihao Cao, Jing Wan, Jing Guo, Nannan Shi   +15 more
wiley   +1 more source

Identification of molecular subtypes and a prognostic signature based on machine learning and purine metabolism-related genes in breast cancer. [PDF]

Medicine (Baltimore)
Huang W, Tang P, Mei J, Zhang Z, Lu G.
europepmc   +1 more source

Evaluation of Torula Yeast (Candida utilis) Single Cell Proteins as a Partial Replacement for Soybean Meal in Broiler Diets: Effects on Productive Performance, Meat Quality Traits, and Plasma Metabolome

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Over recent years the use of yeast in feedstuffs has gained momentum due to novel developments in single‐cell proteins (SCPs). SCPs are considered a sustainable protein source, as their production enable to convert low‐value substrates (including industrial/agricultural wastes) into feed, with a related reduced environmental impact. This study
Jonathan Dayan, Marco Zampiga, Francesca Soglia, Luca Laghi, Elisa Benini, Massimiliano Petracci, Federico Sirri   +6 more
wiley   +1 more source

Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity. [PDF]

Stem Cell Res Ther
Liu X, Zhang H, Yan J, Ye P, Wang Y, Zhang N, Tian Z, Liu B, Yang H.   +8 more
europepmc   +1 more source