Results 221 to 230 of about 1,020,918 (293)

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in <i>C9orf72</i> Amyotrophic Lateral Sclerosis via ADA. [PDF]

Int J Mol Sci
Hall B, Castelli L, Higginbottom A, He J, Zou LN, Walker H, Yagüe-Capilla M, Wong KE, Burrows DJ, George J, Hamer K, Tanner JM, Kyrgiou-Balli E, Ross R, Garland H, Tonkiss E, George R, Webster CP, Smith EF, Timmons HO, Allsop J, Stefanidis N, Ward BD, Lin YH, Highley JR, Azzouz M, West RJH, Rudd SG, Vos KJ, Shaw PJ, Hautbergue GM, Allen SP.   +31 more
europepmc   +1 more source

Catalysis and allostery in bacterial ATP phosphoribosyltransferases

The FEBS Journal, EarlyView.
ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction of L‐histidine biosynthesis. L‐Histidine allosterically inhibits ATPPRT to regulate this energy‐intensive pathway in histidine‐synthesising organisms, such as bacteria, archaea and plants.
Lillian G. Bates, Rafael G. da Silva
wiley   +1 more source

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice. [PDF]

J Cell Mol Med
Alagbe AE, Little-Ihrig L, Mutchler SM, Jackson EK, Novelli EM, Tofovic SP.   +5 more
europepmc   +1 more source

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Temporal metabolic reprogramming in DSS-induced colitis identifies purine metabolism and trigonelline as novel therapeutic targets. [PDF]

Front Pharmacol
Zhang Q, Wang J, Zhang L, Song K, Sun X, Zhang Y, Liu F.   +6 more
europepmc   +1 more source

Genome‐wide association study of morphometric and metabolic characteristics in European populations of the sugar kelp Saccharina latissima

Journal of Phycology, EarlyView.
Abstract The sugar kelp Saccharina latissima is a promising candidate for sustainable aquaculture in the North Atlantic and Northeast Pacific, but genetic improvement has been hindered by a limited understanding of the genetic basis of economically important traits.
Stéphane Mauger, Komlan Avia, Lucie Jaugeon, Paolo Ruggeri, Zofia Nehr, Ousseini Issaka Salia, Jérôme Coudret, Emilie Gouhier, Aurélien Baud, Stéphane Loisel, Antoine Fort, Ronan Sulpice, Christophe Destombe, Philippe Potin, J. Mark Cock, Myriam Valero   +15 more
wiley   +1 more source

Increased Generation of Hypoxanthine: How Adaptation of Purine Metabolism Drives Vascular Remodeling in Pulmonary Hypertension. [PDF]

JACC Basic Transl Sci
Schäfer K.
europepmc   +1 more source

Quantitative Pharmacodynamic Analysis of Trimethoprim‐Sulfonamide Combination Activity Against Staphylococcus pseudintermedius

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Trimethoprim (TMP)‐sulfonamide combinations are widely used in veterinary medicine, yet the quantitative nature of their pharmacodynamic interaction remains incompletely characterised. This study investigated the interaction between TMP and sulfamethoxazole (SMX), sulfadiazine (SDZ) and sulfadimethoxine (SDMX) against two Staphylococcus ...
Andrew Mead, Alexis Viel, Marine Boulanger, Gudrun Overesch, Carl Ekstrand, Pierre‐Louis Toutain, Aude A. Ferran, Ludovic Pelligand   +7 more
wiley   +1 more source

Purine Metabolism Pathway Influence on Running Capacity in Rats. [PDF]

Metabolites
Chen D, Biney CN, Wang Q, Cai M, Cheng S, Chen W, Zhang J, Zhao J, Zhang Y, Zhang W.   +9 more
europepmc   +1 more source

Mutations in SUMO conjugating enzyme reveal contributions of sumoylation to plant stress resilience and yield

New Phytologist, EarlyView.
Mutations in small ubiquitin‐related modifier (SUMO) conjugating enzyme that increase or decrease functionality reveal SUMO contributions to growth and stress resilience. Summary Small ubiquitin‐related modifier (SUMO) conjugation is a fundamental process in all metazoa, with multiple roles in development and stress responses.
Lilian Nehlin, Sadia Sabrina Alam, Junaid Shehzad, Bushra Ijaz, Jose Julián, Nikola Winter, Andreas Bachmair   +6 more
wiley   +1 more source