Results 231 to 240 of about 1,020,918 (293)

Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN. [PDF]

Cancer Med
Jiang Y, Xiao H, Yang Y, Chen G, Zhang Y, Wu X, Zhang Q, Huang Q, Gao H, Han Y, Zhang A, Jiang D, Zheng L, Li Y, Gao Y.   +14 more
europepmc   +1 more source

MYB156 promotes root sucker formation by repressing IDD14 and CKX1 to elevate cytokinin levels in Populus

New Phytologist, EarlyView.
Schematic model illustrating MYB156‐mediated regulatory network controlling root‐sucker formation. Summary Root suckers enable clonal propagation of rooting‐recalcitrant poplars, conferring rejuvenated traits such as enhanced survival and accelerated growth.
Hongying Pang, Biying Li, Yajuan Chen, Liping Ding, Wanwan Lyu, Xiaoqin Wang, Hongzhi Wang, Jianhua Wei, Lin Zheng   +8 more
wiley   +1 more source

Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment. [PDF]

Cell Death Dis
D'Aprile S, Denaro S, Torrisi F, Longhitano L, Giallongo S, Giallongo C, Bontempi V, Bucolo C, Drago F, Mione MC, Li Volti G, Potokar M, Jorgačevski J, Zorec R, Tibullo D, Amorini AM, Vicario N, Parenti R.   +17 more
europepmc   +1 more source

STUDIES ON THE EFFECTS OF PURINES ON METABOLISM

Journal of Biological Chemistry, 1946
openaire   +2 more sources

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study. [PDF]

J Transl Med
Gile B, Bulbule S, Toriola MA, Ruan BT, Marium S, Benko A, Grach S, Mueller M, Bateman L, Bell J, Yellman B, Berner J, Chheda B, Kaufman D, Gottschalk G, Roy A.   +15 more
europepmc   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

<i>Fusobacterium nucleatum</i> plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [PDF]

Gut Microbes
Hou S, Ning T, Liu S, Yang X, Ye H, Zhou Y, Wang C, Zhu J, Lu S, Zhang N, Zhu S.   +10 more
europepmc   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Synergistic Probiotic-Postbiotic Therapy Ameliorates Hyperuricemia via Multi-Target Regulation of Purine Metabolism and Gut Microbiota. [PDF]

Foods
Ren L, Liu S, Wang S, Li Z, Lu F, Luo X.
europepmc   +1 more source