Results 241 to 250 of about 1,551,682 (283)

Purine Metabolism in Trypanosomatids*

The Journal of Protozoology, 1979
SYNOPSIS. Purine nucleotide biosynthesis was studied in culture forms of Trypanosoma cruzi strain Y, Crithidia deanei (a reduviid trypanosomatid with an endosymbiote) and an aposymbiotic strain of C. deanei (obtained by curing C. deanei with chloramphenicol).
C R, Ceron, R D, Caldas, C R, Felix, M H, Mundim, I, Roitman   +4 more
openaire   +2 more sources

Purine and Pyrimidine Metabolism

2013
Purine and pyrimidine nucleotides are essential for a vast number of biological processes such as RNA and DNA synthesis and as a component of high-energy nucleotides, e.g., adenosine triphosphate. Polygenic and Mendelian diseases are associated with altered purine and pyrimidine metabolism; thus, the genes associated with gout have only minor effects ...
Kamatani, Naoyuki, Jinnah, H. A., Hennekam, Raoul C. M., van Kuilenburg, André B. P.   +3 more
openaire   +1 more source

Purine metabolism

Biochemical Society Transactions, 1981
Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
openaire   +2 more sources

Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer.

Drug resistance updates
AIMS Immune checkpoint blockade therapy is not effective in most patients with non-small cell lung cancer (NSCLC) due to the immunosuppressive tumor microenvironment.
Li Yang, Aitian Li, Weina Yu, Huishang Wang, Lei Zhang, Dan Wang, Ying Wang, Ru Zhang, Q. Lei, Zhangnan Liu, Shanshan Zhen, Haiming Qin, Yaqing Liu, Yang Yang, Xian-Lu Song, Yi Zhang   +15 more
semanticscholar   +1 more source

Metabolism of Purines and Pyrimidines

Annual Review of Biochemistry, 1956
The emphasis of recent reviews on structural aspects of nucleic acid chem­ istry and the substantial achievement represented by the publications of the past year on the metabolism of purine and pyrimidine nucleotides has led to the selection of enzymic reactions operative in the synthesis of these com­ pounds as the principal subject of this review ...
openaire   +2 more sources

Mass Spectrometry-Based Metabolomics Reveals Paraben Exposure Related to Purine Metabolism and Other Pathways.

Environmental Science and Technology, 2020
Parabens are widely used as common preservatives in pharmaceutical and cosmetic industries. Exposure to parabens has been found to be associated with metabolic alterations of human and the increased risk of metabolic disease, such as diabetes.
Hongzhi Zhao, Yuanyuan Zheng, Lin Zhu, Li Xiang, Yanqiu Zhou, Jiufeng Li, Jing Fang, Shunqing Xu, W. Xia, Z. Cai   +9 more
semanticscholar   +1 more source

Purine and pyrimidine metabolism in the trypanosomatidae

Molecular and Biochemical Parasitology, 1984
The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
D J, Hammond, W E, Gutteridge
openaire   +2 more sources

Purine Metabolism in Feline Lymphomas

Veterinary Pathology, 1990
Deficiency of the purine metabolic enzyme adenosine deaminase causes severe immunodeficiency. Retroviruses have been reported to decrease the activity of adenosine deaminase, and many retroviruses, including feline leukemia virus, cause immunodeficiency.
E A, Copelan, K S, Waddell, S C, Johnson, L, Mathes   +3 more
openaire   +2 more sources

Purine metabolism in primitive erythrocytes

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973
Abstract 1. 1. The activities of AMP kinase, GMP kinase, NDP kinase, PNPase and HGPRTase were determined in the erythrocytes of seal, eel, hagfish and dogfish. 2. 2. Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined. 3. 3.
R E, Parks, P R, Brown, Y C, Cheng, K C, Agarwal, C M, Kong, R P, Agarwal, C C, Parks   +6 more
openaire   +2 more sources

Metabolism and Ecology of Purine Alkaloids

Frontiers in Bioscience, 2006
In this review, the biosynthesis, catabolism, ecological significance, and modes of action of purine alkaloids particularly, caffeine, theobromine and theophylline in plants are discussed. In the biosynthesis of caffeine, progress has been made in enzymology, the amino acid sequence of the enzymes, and in the genes encoding N-methyltransferases.
Ana Luisa, Anaya, Rocio, Cruz-Ortega, George R, Waller   +2 more
openaire   +2 more sources