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Purine Metabolism in Trypanosomatids*
The Journal of Protozoology, 1979SYNOPSIS. Purine nucleotide biosynthesis was studied in culture forms of Trypanosoma cruzi strain Y, Crithidia deanei (a reduviid trypanosomatid with an endosymbiote) and an aposymbiotic strain of C. deanei (obtained by curing C. deanei with chloramphenicol).
C R, Ceron +4 more
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Biochemical Society Transactions, 1981
Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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Abstract The inherited disorders of purine metabolism associated with renal disease are listed in Table 24.1. They are the sole cause of only a small proportion of all renal disease and are therefore best considered as part of the overall problem of purine, especially uric acid metabolism-related renal disease.
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Purine and Pyrimidine Metabolism
2013Purine and pyrimidine nucleotides are essential for a vast number of biological processes such as RNA and DNA synthesis and as a component of high-energy nucleotides, e.g., adenosine triphosphate. Polygenic and Mendelian diseases are associated with altered purine and pyrimidine metabolism; thus, the genes associated with gout have only minor effects ...
Kamatani, Naoyuki +3 more
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Metabolism of Purines and Pyrimidines
Annual Review of Biochemistry, 1956The emphasis of recent reviews on structural aspects of nucleic acid chem istry and the substantial achievement represented by the publications of the past year on the metabolism of purine and pyrimidine nucleotides has led to the selection of enzymic reactions operative in the synthesis of these com pounds as the principal subject of this review ...
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Purine and pyrimidine metabolism in the trypanosomatidae
Molecular and Biochemical Parasitology, 1984The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
D J, Hammond, W E, Gutteridge
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Purine Metabolism in Feline Lymphomas
Veterinary Pathology, 1990Deficiency of the purine metabolic enzyme adenosine deaminase causes severe immunodeficiency. Retroviruses have been reported to decrease the activity of adenosine deaminase, and many retroviruses, including feline leukemia virus, cause immunodeficiency.
E A, Copelan +3 more
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Purine metabolism in primitive erythrocytes
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973Abstract 1. 1. The activities of AMP kinase, GMP kinase, NDP kinase, PNPase and HGPRTase were determined in the erythrocytes of seal, eel, hagfish and dogfish. 2. 2. Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined. 3. 3.
R E, Parks +6 more
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Metabolism and Ecology of Purine Alkaloids
Frontiers in Bioscience, 2006In this review, the biosynthesis, catabolism, ecological significance, and modes of action of purine alkaloids particularly, caffeine, theobromine and theophylline in plants are discussed. In the biosynthesis of caffeine, progress has been made in enzymology, the amino acid sequence of the enzymes, and in the genes encoding N-methyltransferases.
Ana Luisa, Anaya +2 more
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Purine metabolism in human lymphocytes
Blut, 1979In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with 14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer ...
M M, Müller +4 more
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Disorders of purine and pyrimidine metabolism
Molecular Genetics and Metabolism, 2005The disorders of purine and pyrimidine metabolism are unusual in their variety of clinical presentations and in the mechanisms by which these presentations result from the fundamental mutations. In the most common of the hyperuricemic metabolic disorders, deficiency of hypoxanthine phosphoribosyl transferase, the fundamental deficiency in the activity ...
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