Results 251 to 260 of about 1,551,682 (283)

Purine metabolism in human lymphocytes

Blut, 1979
In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with 14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer ...
M M, Müller, G, Pischek, O, Scheiner, H, Stemberger, G, Wiedermann   +4 more
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Disorders of purine and pyrimidine metabolism

Molecular Genetics and Metabolism, 2005
The disorders of purine and pyrimidine metabolism are unusual in their variety of clinical presentations and in the mechanisms by which these presentations result from the fundamental mutations. In the most common of the hyperuricemic metabolic disorders, deficiency of hypoxanthine phosphoribosyl transferase, the fundamental deficiency in the activity ...
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Enzymes of purine metabolism in cancer

Clinical Biochemistry, 1983
In cancer cells, a marked imbalance in the enzymic pattern of purine metabolism is linked with transformation and/or progression. In chemically-induced, transplantable hepatomas in rat, the specific activities of the anabolic enzymes, IMP dehydrogenase, GMP synthetase, adenylosuccinate synthetase, adenylosuccinase, AMP deaminase and ...
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Dual‐Specificity Tyrosine Phosphorylation–Regulated Kinase 3 Loss Activates Purine Metabolism and Promotes Hepatocellular Carcinoma Progression

Hepatology, 2019
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes.
Fei Ma, Yuekun Zhu, Xing Liu, Qingxin Zhou, Xuehui Hong, C. Qu, Xing Feng, Yiyun Zhang, Qingbin Ding, Jiabao Zhao, Jingjing Hou, Mengya Zhong, Huiqin Zhuo, Lifeng Zhong, Zhijian Ye, Wen Xie, Yu Liu, Yubo Xiong, Hongwei Chen, D. Piao, Bei Sun, Zhi Gao, Qinghua Li, Zhen Zhang, Xingfeng Qiu, Zhiyong Zhang   +25 more
semanticscholar   +1 more source

Purine metabolism in Schistosoma mansoni

International Journal for Parasitology, 1972
Abstract Schistosoma mansoni has been found to have a spectrum of purine nucleotides which is similar, but not identical to mammalian cells. The principal component of this system is ATP, which is present at a level of about 5·5 × 10 −9 moles/mg worm pairs.
A W, Senft, R P, Miech, P R, Brown, D G, Senft   +3 more
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Purine metabolism in Trypanosoma cruzi

Molecular and Biochemical Parasitology, 1981
Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth. Adenine, hypoxanthine, guanine, xanthine and their respective ribonucleosides are equal in their abilities to support growth.
R L, Berens, J J, Marr, S W, LaFon, D J, Nelson   +3 more
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Pathophysiology of Purine Metabolism in Man

Enzyme, 2017
In this review, some of the more recent concepts related to the pathophysiology of purine metabolism in man have been reviewed. Despite the concerted effort of a number of investigators, however, many questions remain unanswered. Hopefully, new clues will be unraveled as clinical and basic scientists continue to embark into may areas in the field which
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The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation.

Science of the Total Environment, 2018
Adipocyte differentiation is closely associated with obesity and obesity-induced metabolic disorders. Epidemiological studies have demonstrated the association of obesity with environmental pollutants, such as polybrominated diphenyl ethers (PBDEs ...
Chunxue Yang, C. Wong, Juntong Wei, A. Chung, Z. Cai   +4 more
semanticscholar   +1 more source

Purine and Pyrimidine Metabolism in Leishmania

2008
Purines and pyrimidines are indispensable to all life, performing many vital functions for cells: ATP serves as the universal currency of cellular energy, cAMP and cGMP are key second messenger molecules, purine and pyrimidine nucleotides are precursors for activated forms of both carbohydrates and lipids, nucleotide derivatives of vitamins are ...
Nicola S, Carter, Phillip, Yates, Cassandra S, Arendt, Jan M, Boitz, Buddy, Ullman   +4 more
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Purine Metabolism in Rat Macrophages

1984
The association of deficiencies of purine metabolic enzymes with immunodeficiency diseases has stimulated research in purine metabolism of lymphoid cells. Up to now our knowledge about purine metabolism of other cells of the immune system, e.g., macrophages, is relatively limited.
J, Barankiewicz, A, Cohen
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