Results 261 to 270 of about 1,297,457 (342)
Utilizing an integrated bioinformatics and machine learning approach to uncover biomarkers linking ulcerative colitis to purine metabolism-related genes. [PDF]
HeliyonChen T +6 more
europepmc +1 more source
Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease
Brain and Behavior, Volume 15, Issue 9, September 2025.This Mendelian randomization study systematically screened 338 cerebrospinal fluid metabolites and identified several with potential causal effects on Parkinson's disease, offering new insights into disease pathogenesis. ABSTRACT Background Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by motor impairments and ...
Houwen Zhang +5 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su +4 more
wiley +1 more source
The Purine and Pyrimidine Metabolism in Lactating Dairy Cows [PDF]
, 2015 Charlotte Stentoft Nielsen
openalex
Drug Testing and Analysis, Volume 17, Issue 9, Page 1750-1758, September 2025.Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy +3 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 9, September 2025.Taste enhancement in Japanese black Wagyu (JBW) beef fed with Sake Lees: Feeding sake lees (SL) to JBW cattle altered beef metabolite profiles, as revealed by metabolomics and taste sensor analysis. Elevated glucose 1‐phosphate and amino acids were associated with enhanced sweetness, consistent with sensory evaluation.
Hitomi Shikano +6 more
wiley +1 more source
Integrated analysis of purine metabolism assists in predicting prognosis and treatment decisions for patients with lung adenocarcinoma. [PDF]
HeliyonZhang T, Chen R, Su X, Wang M, Lu Q.
europepmc +1 more source
MedComm, Volume 6, Issue 9, September 2025.• Whole fecal analysis generated the distinct signature of the gut microbiome and metabolome for HSCT in subjects with time point among generally 59 individuals. • Reduced microbiota diversity in period of HSCT is linked to increased complications, GVHD, and NF with PD.
Juewon Kim +8 more
wiley +1 more source
Purine Metabolism and Hexosamine Biosynthetic Pathway Abnormalities in Diarrheal Weaned Piglets Identified Using Metabolomics. [PDF]
Animals (Basel)Wang M +13 more
europepmc +1 more source
MedComm, Volume 6, Issue 9, September 2025.Postinfectious cough patients have elevated levels of activated IFN‐γ+ T lymphocytes in blood. Postinfectious cough patients exhibit airway inflammatory signatures characterized by activated IFN‐γ+ T‐lymphocytes and elevated levels of IFN‐γ, TNF‐α, IFN‐α, IFN‐β, and IL‐10.
Zheng Deng +7 more
wiley +1 more source