Results 261 to 270 of about 61,638 (306)
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Purine Metabolism and Immunodeficiency
Pediatrics International, 1981Summary Effects of the abnormalities of purine metabolism on the lymphocytes were studied. When the lymphocytes from the patients with Lesch-Nyhan syndrome in which HGPRT is defective were analysed. Immunoglobulin production from B-cells, mitotic response of T-cells, functions of helper T-cells and suppressor T-cells were thought to be impared ...
Junichi Yata, Toshiro Nakagawa
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Disorders of Purine and Pyrimidine Metabolism
2000Inborn errors of purine and pyrimidine metabolism manifest themselves by a variety of clinical pictures. Table I gives a list of the major presenting signs and laboratory results that should lead to further investigations to rule out or to confirm the diagnostic possibilities listed.
Sandrine Marie +2 more
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, 1988 The purpose of purine metabolism in man is to maintain an optimal level of the nucleotides in the tissues. The nucleotides play an important role in nearly all biochemical processes, including energy metabolism, DNA and RNA structure, and regulation of many metabolic pathways through allosteric effects on enzymes, or through the adenylate energy charge.
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The purine metabolism of human erythrocytes
Biochemistry (Moscow), 2006This review summarizes currently available information about a crucial part of erythrocyte metabolism, that is, purine nucleotide conversions and their relationships with other conversion pathways. We describe the cellular resynthesis, interconversion, and degradation of purine compounds, and also the regulatory mechanisms in the conversion pathways ...
E. Skotnicka +3 more
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Purine metabolism in Schistosoma mansoni
International Journal for Parasitology, 1972Abstract Schistosoma mansoni has been found to have a spectrum of purine nucleotides which is similar, but not identical to mammalian cells. The principal component of this system is ATP, which is present at a level of about 5·5 × 10 −9 moles/mg worm pairs.
Alfred W. Senft +3 more
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Purine and pyrimidine metabolism in the trypanosomatidae
Molecular and Biochemical Parasitology, 1984The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
David J. Hammond, Winston E. Gutteridge
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Metabolism of endogenous purines
1991Much of our insight into the importance of specific enzymes governing sequential steps in purine metabolism has derived from the discovery of individuals with an inherited deficiency of one of these enzymes (see Chapter 11). This has been particularly important for understanding the mechanisms responsible for the regulation of purine biosynthesis and ...
T. W. Stone, H. A. Simmonds
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Purine metabolism in primitive erythrocytes
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973Abstract 1. 1. The activities of AMP kinase, GMP kinase, NDP kinase, PNPase and HGPRTase were determined in the erythrocytes of seal, eel, hagfish and dogfish. 2. 2. Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined. 3. 3.
Phyllis R. Brown +6 more
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Metabolism and Ecology of Purine Alkaloids
Frontiers in Bioscience, 2006In this review, the biosynthesis, catabolism, ecological significance, and modes of action of purine alkaloids particularly, caffeine, theobromine and theophylline in plants are discussed. In the biosynthesis of caffeine, progress has been made in enzymology, the amino acid sequence of the enzymes, and in the genes encoding N-methyltransferases.
George R Waller +2 more
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Archives of Internal Medicine, 1968
This book contains the proceedings of the conference on Gout and Purine Metabolism held in October 1964. Originally published as a supplement to Arthritis and Rheumatism , it is now being offered in hardback form. All of the recognized authorities have contributed, and a great deal of data has been collected in one place. It must be recognized, however,
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This book contains the proceedings of the conference on Gout and Purine Metabolism held in October 1964. Originally published as a supplement to Arthritis and Rheumatism , it is now being offered in hardback form. All of the recognized authorities have contributed, and a great deal of data has been collected in one place. It must be recognized, however,
openaire +2 more sources