Results 271 to 280 of about 61,638 (306)
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Enzymes of purine metabolism in cancer
Clinical Biochemistry, 1983In cancer cells, a marked imbalance in the enzymic pattern of purine metabolism is linked with transformation and/or progression. In chemically-induced, transplantable hepatomas in rat, the specific activities of the anabolic enzymes, IMP dehydrogenase, GMP synthetase, adenylosuccinate synthetase, adenylosuccinase, AMP deaminase and ...
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Disorders of Purine and Pyrimidine Metabolism [PDF]
, 1976 Substantial progress has been made in the past year in identifying new primary disorders associated with abnormalities of purine and pyrimidine metabolism, in defining more precisely the metabolic consequences of specific enzyme defects, and in deducing the mechanisms involved in producing their clinical expression.
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Disorders of purine and pyrimidine metabolism
Molecular Genetics and Metabolism, 2005The disorders of purine and pyrimidine metabolism are unusual in their variety of clinical presentations and in the mechanisms by which these presentations result from the fundamental mutations. In the most common of the hyperuricemic metabolic disorders, deficiency of hypoxanthine phosphoribosyl transferase, the fundamental deficiency in the activity ...
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Purine and Pyrimidine Metabolism in Leishmania
2008Purines and pyrimidines are indispensable to all life, performing many vital functions for cells: ATP serves as the universal currency of cellular energy, cAMP and cGMP are key second messenger molecules, purine and pyrimidine nucleotides are precursors for activated forms of both carbohydrates and lipids, nucleotide derivatives of vitamins are ...
Phillip A. Yates +4 more
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Metabolism of Pyrimidines and Purines
1982As in bacterial and animal systems, the purine and pyrimidine nucleotides in plants as well as their derivatives are operative as constituents of nucleic acids and coenzymes as well as in regulatory acting Compounds. They are involved in the synthesis of thiamine, riboflavine, folic acid pteridines, histidine, or are constituents of cytokinins, purine ...
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Antipurines and Purine Metabolism
1988The study of the involvement of purines in lymphocyte function has been highlighted by two dramatic and unrelated discoveries. The first, the discovery in 1958 that 6-mercaptopurine (6-MP) had marked immunosuppressive properties (Schwartz et al. 1958), was followed by the wide use of its S-substituted analog, azathioprine (Aza), to prevent rejection of
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Extracellular purine metabolism
Drug Development Research, 1996A variety of nucleotides and the nucleoside adenosine can act as extracellular signaling substances. Their function is terminated by extracellular degradation via surface-located enzymes. The breakdown products may be recycled. This review discusses recent developments in the cellular and molecular biology of enzymes involved in extracellular purine ...
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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Targeting cancer metabolism in the era of precision oncology
Nature Reviews Drug Discovery, 2022Arantxa Gorostiaga +2 more
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