Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment [PDF]
Advanced ScienceSmall colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi +11 more
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HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground The mutations of oncogenic epidermal growth factor receptor (EGFR) is an important cause of lung adenocarcinoma (LUAD) malignance. It has been knowm that metabolic reprogramming is an important hallmark of malignant tumors, and purine ...
Pengyu Geng +10 more
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Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning [PDF]
Scientific Reports, 2023 Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations. While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms ...
Zixuan Wu +4 more
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Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria
eLife, 2018 Gene control systems sometimes interpret multiple signals to set the expression levels of the genes they regulate. In rare instances, ligand-binding riboswitch aptamers form tandem arrangements to approximate the function of specific two-input Boolean ...
Madeline E. Sherlock +3 more
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THE PURINE METABOLISM OF ESCHERICHIA COLI
Journal of Biological Chemistry, 1952 Arthur L. Koch +2 more
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A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma
Frontiers in Genetics, 2022 Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang +5 more
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Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data
Frontiers in Molecular Neuroscience, 2023 IntroductionPrevious studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism of ...
Si Dai +5 more
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Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation
Zoological Research, 2022 Many mammals risk damage from oxidative stress stemming from frequent dives (i.e., cycles of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean environments, or powered flight.
Ran Tian +5 more
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Metabolic reprogramming provides a new perspective for understanding cancer. The targeting of dysregulated metabolic pathways may help to reprogram the immune status of the tumor microenvironment (TME), thereby increasing the effectiveness of
Hui Liu +4 more
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New Phytologist, 2021 Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage-specific regulation is unclear.
Manli Sun +9 more
semanticscholar +1 more source