Results 21 to 30 of about 1,394,357 (370)

Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma

Molecular & Cellular Oncology, 2020
Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma.
Weihua Zhou, Daniel R Wahl
doaj   +2 more sources

Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose

Redox Biology, 2016
Complex metabolism is thought to occur exclusively in the crowded intracellular environment. Here we report that diluted enzymes from lysed human leukocytes produce extracellular energy.
John B. Hibbs Jr., Zdenek Vavrin, James E. Cox   +2 more
doaj   +2 more sources

Purine metabolism in the development of osteoporosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Keda Yang, Jie Li, Lin Tao
semanticscholar   +2 more sources

Purine Metabolism in Toxoplasma gondii

Journal of Biological Chemistry, 1989
We have studied the incorporation and interconversion of purines into nucleotides by freshly isolated Toxoplasma gondii. They did not synthesize nucleotides from formate, glycine, or serine. The purine bases hypoxanthine, xanthine, guanine, and adenine were incorporated at 9.2, 6.2, 5.1, and 4.3 pmol/10(7) cells/h, respectively.
E C, Krug, J J, Marr, R L, Berens
openaire   +3 more sources

Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment [PDF]

Advanced Science
Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi, Qiong Wu, Zesong Ruan, Zhiyuan Luo, Wenbo Wang, Zhao Guo, Yihong Ma, Xin Wang, Guangyu Chu, Han Lin, Min Ge, Yunfeng Chen   +11 more
doaj   +2 more sources

Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN. [PDF]

Cancer Med
Jiang Y, Xiao H, Yang Y, Chen G, Zhang Y, Wu X, Zhang Q, Huang Q, Gao H, Han Y, Zhang A, Jiang D, Zheng L, Li Y, Gao Y.   +14 more
europepmc   +3 more sources

Serum p-Cresol and 7-HOCA Levels and Fatty Acid and Purine Metabolism Are Associated with Survival, Progression, and Molecular Classification in GB-Serum Proteome and Metabolome Analysis Pre vs. Post Up-Front Chemoirradiation. [PDF]

Curr Oncol
Krauze AV, Li M, Zhao Y, Tasci E, Chappidi S, Cooley Zgela T, Sproull M, Mackey M, Camphausen K.   +8 more
europepmc   +3 more sources

Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse ...
S. I. Vorotyntsev, A. I. Bilai, I. M. Bilai   +2 more
doaj   +1 more source

Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential

International Journal of Molecular Sciences, 2023
Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
A. Cicero, F. Fogacci, Valentina Di Micoli, C. Angeloni, M. Giovannini, C. Borghi   +5 more
semanticscholar   +1 more source

Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data

Frontiers in Molecular Neuroscience, 2023
IntroductionPrevious studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism of ...
Si Dai, Jingjing Lin, Yanting Hou, Xuerong Luo, Yidong Shen, Jianjun Ou   +5 more
doaj   +1 more source