Results 321 to 330 of about 1,394,357 (370)

Purine metabolism in human lymphocytes

Blut, 1979
In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with 14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer ...
M M, Müller, G, Pischek, O, Scheiner, H, Stemberger, G, Wiedermann   +4 more
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Purine metabolism in primitive erythrocytes

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973
Abstract 1. 1. The activities of AMP kinase, GMP kinase, NDP kinase, PNPase and HGPRTase were determined in the erythrocytes of seal, eel, hagfish and dogfish. 2. 2. Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined. 3. 3.
R E, Parks, P R, Brown, Y C, Cheng, K C, Agarwal, C M, Kong, R P, Agarwal, C C, Parks   +6 more
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Macitentan attenuates chronic mountain sickness in rats by regulating arginine and purine metabolism.

Journal of Proteome Research, 2020
Chronic mountain sickness (CMS) is a high-altitude complication with high rates of morbidity and mortality. CMS is characterized by high-altitude polycythemia (HAPC) and high-altitude pulmonary hypertension (HAPH).
Xiaojian Gao, Zeyu Zhang, Xin Li, Chen Li, Jianxiu Hao, Yunfu Luo, Maoyi Lei, Junmiao Li, Chunlei Liu, K. He   +9 more
semanticscholar   +1 more source

Purine metabolism in Trypanosoma cruzi

Molecular and Biochemical Parasitology, 1981
Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth. Adenine, hypoxanthine, guanine, xanthine and their respective ribonucleosides are equal in their abilities to support growth.
R L, Berens, J J, Marr, S W, LaFon, D J, Nelson   +3 more
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Dual‐Specificity Tyrosine Phosphorylation–Regulated Kinase 3 Loss Activates Purine Metabolism and Promotes Hepatocellular Carcinoma Progression

Hepatology, 2019
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes.
Fei Ma, Yuekun Zhu, Xing Liu, Qingxin Zhou, Xuehui Hong, C. Qu, Xing Feng, Yiyun Zhang, Qingbin Ding, Jiabao Zhao, Jingjing Hou, Mengya Zhong, Huiqin Zhuo, Lifeng Zhong, Zhijian Ye, Wen Xie, Yu Liu, Yubo Xiong, Hongwei Chen, D. Piao, Bei Sun, Zhi Gao, Qinghua Li, Zhen Zhang, Xingfeng Qiu, Zhiyong Zhang   +25 more
semanticscholar   +1 more source

Metabolism of Purines and Pyrimidines

Annual Review of Biochemistry, 1956
The emphasis of recent reviews on structural aspects of nucleic acid chem­ istry and the substantial achievement represented by the publications of the past year on the metabolism of purine and pyrimidine nucleotides has led to the selection of enzymic reactions operative in the synthesis of these com­ pounds as the principal subject of this review ...
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Endothelial Purine Metabolism and Reperfusion Injury

Clinical Biochemistry, 1997
The endothelium shows high metabolic activity and thus influences a great number of physiological processes. Eicosanoids, thrombomodulin, protein S, and von Willebrand factor are important for the regulation of blood coagulation. By releasing eicosanoids and nitric oxide the endothelium is involved in the regulation of the vascular tone. Growth factors,
G, Weigel, A, Griesmacher, M M, Müller
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Extracellular purine metabolism

Drug Development Research, 1996
A variety of nucleotides and the nucleoside adenosine can act as extracellular signaling substances. Their function is terminated by extracellular degradation via surface-located enzymes. The breakdown products may be recycled. This review discusses recent developments in the cellular and molecular biology of enzymes involved in extracellular purine ...
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PURINE METABOLISM IN NEISSERIA MENINGITIDIS

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1975
Radioactive hypoxanthine and adenine were readily incorporated into the nucleic acids (RNA + DNA) of the prototrophic strain M1 of Neisseria meningitidis with labelling of the purine bases adenine and guanine. Contrary to this, adenine was incorporated into the nucleic acids with labelling of adenine only in the purine mutant 6‐1c which requires ...
S, Jyssum, K, Jyssum
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Human Purine Metabolism

1988
The purpose of purine metabolism in man is to maintain an optimal level of the nucleotides in the tissues. The nucleotides play an important role in nearly all biochemical processes, including energy metabolism, DNA and RNA structure, and regulation of many metabolic pathways through allosteric effects on enzymes, or through the adenylate energy charge.
openaire   +1 more source