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Purine Metabolism in Rat Macrophages
1984The association of deficiencies of purine metabolic enzymes with immunodeficiency diseases has stimulated research in purine metabolism of lymphoid cells. Up to now our knowledge about purine metabolism of other cells of the immune system, e.g., macrophages, is relatively limited.
J, Barankiewicz, A, Cohen
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Immunological Aspects of Purine Metabolism
1977The development of our knowledge of the immune system has been reviewed and evidence presented of the need for a rapid rate of purine synthesis de novo for the proliferative events in this process. The mechanism of the inhibition of the immune system in a model of ADA deficiency has been studied intensively and considerable indirect evidence obtained ...
J E, Seegmiller +3 more
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Nutritional State and Purine Metabolism
1977Hyperuricemia and gout are multifarious disorders of purine metabolism with heredity as genetic base and exogenic environmental factors which are prevailing of alimentary nature including overcaloric and fatty nutrition and alcohol consumption. These latter factors may be able to induce the manifestation of clinical gout.
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Disorders of Purine Metabolism
1991Gout is a heterogeneous group of disorders of purine metabolism which leads to hyperuricemia and arthritis as well as gout nodules (tophi) from deposition of urate crystals in and around the joints and in the skin. The hyperuricemia in primary gout is related to overproduction or reduced renal excretion of uric acid, while in secondary gout it is due ...
Otto Braun-Falco +3 more
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
exaly
Metabolic Support: Modulation of Purine Metabolism
1993As the major substrate of energy-consuming reactions, ATP plays a key role in cell metabolism. Hypoxia and ischemia impair the mitochondrial process of oxidative phosphorylation, resulting in a net catabolism of ATP. A primary goal of metabolic support should thus be the preservation of cellular ATP levels.
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