Results 61 to 70 of about 73,159 (260)

NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance

Cell Death and Disease
De novo purine synthesis metabolism plays a crucial role in tumor cell survival and malignant progression. However, the specific impact of this metabolic pathway on chemoresistance in ovarian cancer remains unclear.
Jingchun Liu, Haoyu Wang, Huanzhi Wan, Jiang Yang, Likun Gao, Zhi Wang, Xiaoyi Zhang, Wuyue Han, Jiaxin Peng, Lian Yang, Li Hong   +10 more
doaj   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle.

PLoS Computational Biology, 2015
Metabolism is the major output of the circadian clock in many organisms. We developed a computational method to integrate both circadian gene expression and metabolic network.
Ying Li, Guang Li, Benjamin Görling, Burkhard Luy, Jiulin Du, Jun Yan   +5 more
doaj   +1 more source

Purine metabolism in Echinococcus multilocularis

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1998
The activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its purine requirement. Therefore, these enzymes may be targets for drugs in the chemotherapeutic treatment of diseases caused by ...
Suchail, S, Sarciron, M, Petavy, A
openaire   +3 more sources

Grape Seed Polyphenols Enhance Antioxidant Activity and Prolong the Lifespan of Caenorhabditis elegans Through SKN‐1/Nrf2 Pathway

AgriFood: Journal of Agricultural Products for Food, EarlyView.
GSP extends C. elegans lifespan, enhances stress resistance and reproduction, boosts antioxidant defenses (↑SOD/CAT/GSH‐Px, ↓ROS), remodels glycolysis/TCA/one‐carbon metabolism dose‐dependently, and activates SKN‐1/Nrf2 and H3K4 methylation—linking redox control to epigenetic modulation.
Boya Ouyang, Quanyong Wu, Fei Liu, Jingyimei Liang, Wanning Ma, Yuxuan Zhao, Hui Cao, Jianbo Xiao   +7 more
wiley   +1 more source

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Advanced Science
Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, and cognitive impairments.
Ben Lin, Zhen Ye, Zhan Cao, Zhao Ye, Yifei Yu, Weiliang Jiang, Sichen Guo, Vladimir Melnikov, Peng Zhou, Chenxing Ji, Chengzhang Shi, Zerui Wu, Zhengyuan Chen, Yihua Xu, Qilin Zhang, Zengyi Ma, Nidan Qiao, Long Chen, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Li Zhang, Min He, Yongfei Wang, Hongying Ye, Yiming Li, Zhaoyun Zhang, Meng Wang, Renyuan Gao, Yichao Zhang   +29 more
doaj   +1 more source

Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis

Cell Death and Disease
Osteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay ...
Keda Yang, Xiaochuan Wang, Chi Zhang, Dian Liu, Lin Tao   +4 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Purine and Pyrimidine Metabolism: New Challenges

Nucleosides, Nucleotides and Nucleic Acids, 2004
In 2003 a joint International and European symposium on Purines and Pyrimidines was held in the Netherlands.
Peters, G. J., van Kuilenburg, A. B. P., de Abreu, R. A., van Kuilenberg, ABP   +3 more
openaire   +4 more sources

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source