Results 61 to 70 of about 1,394,357 (370)

Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]

, 1994
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O, Fujita, S, Hamamoto, I, Irish, W, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Van Gulik, TM   +8 more
core   +1 more source

Disorders of purine biosynthesis metabolism

Molecular Genetics and Metabolism, 2022
Purines are essential molecules that are components of vital biomolecules, such as nucleic acids, coenzymes, signaling molecules, as well as energy transfer molecules. The de novo biosynthesis pathway starts from phosphoribosylpyrophosphate (PRPP) and eventually leads to the synthesis of inosine monophosphate (IMP) by means of 10 sequential steps ...
Dewulf, Joseph P, Marie, Sandrine, Nassogne, Marie-Cécile   +2 more
openaire   +5 more sources

Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression

Hepatology Communications, 2020
Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development.
Y. Chong, T. Toh, Zhiling Chan, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, L. Hooi, Zhaobing Ding, T. Shuen, H. Toh, Y. Dan, G. Bonney, Lei Zhou, P. Chow, Yulan Wang, T. Benoukraf, E. Chow, W. Han   +16 more
semanticscholar   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A., Dugas, Martin, Heizmann, O., Martignoni, A., Messmer, K., Peter, K., Rau, H. G., Schauer, R. J., Thiel, M., Volk, A.   +9 more
core   +1 more source

Cadmium exposure dysregulates purine metabolism and homeostasis across the gut-liver axis in a mouse model

Ecotoxicology and Environmental Safety, 2023
Cadmium (Cd) exposure has been associated with the development of enterohepatic circulation disorders and hyperuricemia, but the possible contribution of chronic low-dose Cd exposure to disease progression is still need to be explored.
Hui Zhang, Meng Xiu, Hailong Li, Maichao Li, Xiaomei Xue, Yuwei He, Wenyan Sun, Xuan Yuan, Zhen Liu, Xinde Li, Tony R. Merriman, Changgui Li   +11 more
doaj   +1 more source

STUDIES ON PURINE METABOLISM

Journal of Biological Chemistry, 1931
Frank Worthington Allen, Leopold R. Cerecedo   +1 more
openaire   +2 more sources

Investigating the Vital Role of the Identified Abietic Acid from Helianthus annuus L. Calathide Extract against Hyperuricemia via Human Embryonic Kidney 293T Cell Model

Molecules, 2023
To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai, Xiao Xu, Wannan Li, Xueqi Fu, Weiwei Han, Guodong Li   +5 more
doaj   +1 more source

Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]

, 2016
Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA, De Clercq, Rebecca, De Coninck, Barbara, De Jaeger, Geert, Fernie, Alisdair R, Gevaert, Kris, Goossens, Alain, Iñigo, Sabrina, Klassen, Roland, Le Gall, Sabine, Leidel, Sebastian A, Nagels Durand, Astrid, Pauwels, Laurens, Ritter Traub, Andrés, Schaffrath, Raffael, Termathe, Martin, Tohge, Takayuki, Van Leene, Jelle, Van Lijsebettens, Maria   +18 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease [PDF]

, 2016
Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides.
AM Geurts, C Tong, CL Wu, D Pelled, DJ Creek, DJ Williamson, E Zoref-Shani, GD Zheng, GH Guibinga, GH Guibinga, GR Breese, HA Jinnah, HA Jinnah, HA Jinnah, HA Simmonds, K Blair, KG Lloyd, M Buehr, M Hooper, M Lesch, M Mazzali, MA Cenci, MG Garcia, MK Dienhart, MR Kuehn, P Li, QL Ying, RJ Torres, S Brosh, S Finger, S Meek, S Meek, S Wolf, SB Dunnett, SL Meddle, SM Downs, SM Downs, TJ Aitman, TP Yang, TP Zwaka, WJ Tax, WL Nyhan, WL Nyhan, X Zheng, Y Chen, Y Yu   +45 more
core   +4 more sources