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In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis. [PDF]

open access: yesJ Immunol Res, 2017
Carvalho NB   +10 more
europepmc   +1 more source

Bioenergetics of protein transport into mitochondria [PDF]

open access: yes, 1988
Döhren, H. von   +4 more
core  
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Symmetric Nucleosides as Potent Purine Nucleoside Phosphorylase Inhibitors.

The Journal of Physical Chemistry B, 2021
Nucleic acids are one of the most enigmatic biomolecules crucial to several biological processes. Nucleic acid-protein interactions are vital for the coordinated and controlled functioning of a cell, leading to the design of several nucleoside/nucleotide
Pradeep Pant, A. Pathak, B. Jayaram
semanticscholar   +4 more sources

Mutations in purine nucleoside phosphorylase deficiency

Human Mutation, 1997
Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A174P and G190V, a single codon deletion, delta I129, and a ...
Harold R. Collard   +9 more
openaire   +3 more sources

Purine nucleoside phosphorylase of chicken liver

Biochimica et Biophysica Acta (BBA) - Enzymology, 1971
Abstract Purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) has been purified 125-fold from the homogenate of chicken livers and some of the properties of the purified enzyme have been studied. This enzyme had a pH optimum at around 6.o. At high substrate levels of inosine the reaction rate was increased,
Keizo Tsushima   +2 more
openaire   +3 more sources

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