Results 101 to 110 of about 78,151 (289)

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Dampening of neurotransmitter action: molecular similarity within the melatonin structure

Endocrine Regulations, 2018
Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj   +1 more source

Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. [PDF]

Int J Mol Sci, 2021
Tomczyk M, Glaser T, Slominska EM, Ulrich H, Smolenski RT.   +4 more
europepmc   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast.

PLoS Biology
De novo purine synthesis (DPS) is up-regulated under conditions of high purine demand to ensure the production of genetic materials and chemical energy, thereby supporting cell proliferation.
Masak Takaine, Rikuri Morita, Yuto Yoshinari, Takashi Nishimura   +3 more
doaj   +1 more source

RNA Catabolites Contribute to the Nitrogen Pool and Support Growth Recovery of Wheat

Frontiers in Plant Science, 2018
Turn-over of RNA and catabolism of nucleotides releases one to four ammonia molecules; the released nutrients being reassimilated into primary metabolism.
Vanessa Jane Melino, Vanessa Jane Melino, Alberto Casartelli, Jessey George, Thusitha Rupasinghe, Ute Roessner, Mamoru Okamoto, Sigrid Heuer, Sigrid Heuer   +8 more
doaj   +1 more source

Electronic localization at mesoscopic length scales: different definitions of localization and contact effects in a heuristic DNA model

, 2012
In this work we investigate the electronic transport along model DNA molecules using an effective tight-binding approach that includes the backbone on site energies.
A. Kotlyar, A. Rakitin, A.-M. Guo, B. Kramer, C.-T. Shih, C.-T. Shih, C.D. Pemmaraju, C.J. Páez, C.M. Guedon, Carlos J. Páez, D. Porath, D.H. Dunlap, D.K. Klotsa, D.N. Beratan, E. Abrahams, E. Braun, E. Hofstetter, E. Maciá, E. Maciá, E. Shapir, F.A.B.F. Moura de, G. Cuniberti, G.J. Kissel, H. Carrillo-Nuñez, H. Cohen, H. Mehrez, H.-W. Fink, J. Berashevich, J. Rak, J.-F. Feng, J.T. Edwards, K.-H. Yoo, M. Bockrath, M.P.L. Sancho, M.W. Shinwari, N.B. Larsen, P.J. Pablo, Peter A. Schulz, R. Gutiérrez, R. Johnston, R.C.P. Carvalho, R.G. Endres, S. Roche, S.A. Wells, S.S. Mallajosyula, T. Guhr, T. Kottos, V.M.K. Bagci, X. Guo   +48 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source