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Disturbances of purine nucleotide metabolism in uremia [PDF]

Seminars in Nephrology, 2004
The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. It is believed that hyperphosphatemia and metabolic acidosis triggering enhanced reutilization of purine bases are the ...
Przemysław Rutkowski, Ryszard T. Smolenski, T. Ewa Slominska, T. Barbara Butto, Julian Swierczynski, T. Marek Szolkiewicz, Bolesław Rutkowski, T. Maciej Marlewski   +7 more
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Purine Nucleotide Catabolism in Rat Liver

2006
The higher specific radioactivity of ALL in comparison to UA, which are observed after administration of labelled precursors, changed when, oxonic acid and allopurinol, inhibitors of UA and ALL formation were administrated. To interpret these results, it is worth while to recall that nucleotide metabolism can be represented as a complex sequence ...
Marinello E., Pagani R., Arezzini L., Porcelli B., Cinci G., Terzuoli L.   +5 more
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3 Purine, Purine Nucleoside, and Purine Nucleotide Aminohydrolases

1971
Publisher Summary This chapter discusses the chemical significance of adenosine aminohydrolase, 5′-adenylic acid aminohydrolase, adenine nucleoside, nucleotide aminohydrolase, guanine aminohydrolase, and guanosine aminohydrolase. The partially purified adenine aminohydrolase from Azotobacter vinelandii catalyzes the anaerobic conversion of adenine ...
C.H. Suelter, C.L. Zielke
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[26] Aromatic thioethers of purine nucleotides

1977
Publisher Summary Modification of the SH-group of 6-mercaptopurine by suitable substituents results in strong activation of the thioether bonds. A family of substances has been used to attach a covalent label to amino acid side chains, preferentially to the SH group.
Franz Ortanderl, Michael Rack, Franz W. Hulla, Hugo Fasold   +3 more
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Purine nucleotide-metal complexes

Inorganica Chimica Acta, 1987
Abstract Some results of structural studies on metal- purine nucleotide compounds are presented. The X-ray analysis of a new crystalline form of a copper(II)- inosine monophosphate complex reveals interesting conformational features in the nucleoside moieties. The ‘phosphate only’ binding mode seems to be the preferred one for ternary complexes of Mg(
Gianluca Giorgi, Renzo Cini
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Thermodynamics of the purine nucleotide cycle

Biophysical Chemistry, 2006
Since the standard Gibbs energies of formation are known for all the species in the purine nucleotide cycle at 298.15 K, the functions of pH and ionic strength that yield the standard transformed Gibbs energies of formation of the ten reactants can be calculated.
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Degradation of Purine Nucleotides

1978
Purine nucleotides have a vital role in metabolism. Therefore, the maintenance of a constant nucleotide composition of the cell is essential for normal function. Purine nucleotides are synthesized by purine biosynthesis de novo, by salvage pathways and nucleoside kinases, and by degradation of nucleic acids.
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Purine Nucleotide Interconversions

1978
The various reactions of purine ribonucleotide synthesis result in the formation of adenylate, inosinate, and guanylate; xanthylate may also be formed, but this seems to be a quantitatively minor process in most mammalian cells. These purine ribonucleoside monophosphates can be metabolized in several different ways; these processes can in general be ...
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De Novo Purine Nucleotide Biosynthesis

1992
This chapter reviews current understanding of de novo purine nucleotide synthesis in Bacillus subtilis,with emphasis on recent developments in understanding gene organization and regulation and on the distinctive structural features of two enzymes of the pathway.
Jack E. Dixon, Howard Zalkin
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Studies of the Regulation of Purine Nucleotide Catabolism

Canadian Journal of Biochemistry, 1975
Ehrlich ascites tumor cells containing radioactive ATP were incubated in vitro with a range of concentrations of 2-deoxyglucose in order to produce different rates of ATP catabolism. Concentrations of all radioactive products of ATP catabolism were measured, and apparent rates of adenylate deaminase and inosinate dehydrogenase and of adenylate and ...
Bagnara As, Henderson Jf, Lomax Ca
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