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The Purine Nucleotide Cycle Revised
International Journal of Sports Medicine, 1990This review is restricted to the operation of the purine cycle in mammalian muscle. A previous review provided a summary of early evidence for the operation of the cycle and of various functions proposed for the cycle. It also provided a brief history of work on ammonia production by muscle and other tissues and of the discovery of the enzymes of the ...
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Purine nucleotide biosynthesis in gastrointestinal mucosa
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract Two methods were used to elucidate the relative dependence of intestinal mucosa on the alternative pathways of purine nucleotide biosynthesis. While salvage activity was high, there was no evidence of active de novo purine synthesis by either method, suggesting that intestinal mucosa is dependent on salvage pathway activity for the provision
D.J. Deller, A.M. Mackinnon
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Purine nucleotides as regulators of vessel tone
Biochemical Society Transactions, 19885‘-isobutylthioadenosine, but it was inhibited by 10 mMp-nitrophenylphsphate to 50 k 11% ( n = 6). The inhibition of the pigeon ventricle AMPase by other nucleoside monophosphates (with specificity for the base moeity), but not by ribose phosphate or B-glycerophosphate, indicates the presence of a 5’-nucleotidase.
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Patterns of purine nucleotides in fish erythrocytes
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19791. The purine nucleotides were determined in the whole blood of 9 fresh water teleosts and 2 marine selachians. 2. GTP and ATP accounted for 88-99% of the total erythrocytes purines. 3. The ATP/ADP ratio ranged from 11 to 60 in the erythrocytes of the fish examined. 4.
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Electroanalysis, 1994
AbstractFour hydrolases (alkaline phosphatase, apyrase, 5′‐nucleotidase, and adenosine‐5′‐triphosphatase) are immobilized onto the controlled‐pore glass, respectively. They are used as the reactor for the enzyme‐catalyzed hydrolytic cleavage of purine nucleotides, in a flow‐injection system based on the combined use of the following coimmobilized ...
Kiminori Tsureyama +2 more
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AbstractFour hydrolases (alkaline phosphatase, apyrase, 5′‐nucleotidase, and adenosine‐5′‐triphosphatase) are immobilized onto the controlled‐pore glass, respectively. They are used as the reactor for the enzyme‐catalyzed hydrolytic cleavage of purine nucleotides, in a flow‐injection system based on the combined use of the following coimmobilized ...
Kiminori Tsureyama +2 more
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Activation of aspartate transcarbamoylase by purine nucleotides
Biochimica et Biophysica Acta (BBA) - Enzymology, 1970Abstract 1. 1. A previous report demonstrated an increase in aspartate transcarbamoylase activity (carbamoylphosphate: l -aspartate carbamoyltransferase, EC 2.1.3.2) upon incubation of an homogenate of Escherichia coli with ATP, GTP, phosphoenolpyruvate, amino acids and magnesium acetate.
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Purine Nucleotide Content in the Leukocytes of Leukemia Patients
1995Purine nucleotides play an important role in cell life: they are precursors of RNA and DNA, and act as coenzymes and condensers of energy. The evaluation of their metabolism under physiological and pathological conditions is therefore of great interest.
Carlucci F. +8 more
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, 2015 Purine Nucleotide Imbalance in Immunodeficiency Disorders
1985In 1972, Dr Hilaire Meuwissen of Albany, New York, sent some blood samples to Eloise Giblett of the Puget Sound Blood Center, Seattle, Washington, for analysis of genetic markers. One of the blood samples was from a patient with severe combined immunodeficiency disease and the other samples were from the patient’s parents Dr.
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Purine Nucleotide Restoration in HPRT- Cells
1989Lesch-Nyhan syndrome is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) (1, 2). This enzyme catalyzes the conversion of the purine bases hypoxanthine and guanine to their respective 5′ribo-nucleotides. It is reasonable to assume that a deficiency of HPRT would cause a decrease in the cellular concentrations of
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