Results 1 to 10 of about 1,417,283 (133)

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]

Journal of Innate Immunity
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde, Debananda Gogoi, Rory Baird, Cormac McCarthy, Michael P. Keane, Emer P. Reeves, Emmet E. McGrath   +6 more
doaj   +6 more sources

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Computational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee   +3 more
doaj   +2 more sources

Purinergic Receptor P2Y2 Regulates Neurogenesis and Functional Recovery Following Spinal Cord Injury in Zebrafish. [PDF]

FASEB J
Although purinergic P2Y2 receptor can regulate neural stem cell (NSC) proliferation and neurogenesis in mammals, it is downregulated following spinal cord injury (SCI). It was previously unknown whether this receptor regulates these processes in the more‐regenerative zebrafish model, where the contribution of these responses allows near‐complete ...
Sullivan IJ, Stefanova EE, Chinn MC, Burke TA, Fitzgerald BG, Sorbara MT, Van Raay TJ, Scott AL.   +7 more
europepmc   +2 more sources

Purinergic Signalling: Therapeutic Developments [PDF]

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +4 more sources

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival [PDF]

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +2 more sources

P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies. [PDF]

J Immunol Res
Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease‐modulating effects and ...
Pereira TC, Rocha L, Faria RX.
europepmc   +2 more sources

Quantifying Heteromer Partitioning Reveals Inflammation-Dependent Redistribution of Microglial Adenosine A_2A and Cannabinoid CB₂ Receptors. [PDF]

Glia
Proinflammatory activation reorganizes microglial A2A and CB2 receptors, promoting their incorporation into stable heteromers and blocking agonist‐induced redistribution. The results reveal those heteromers as potential therapeutic targets in inflammatory contexts.
Franco R, Lillo J, Griñán-Ferré C, Pallàs M, Rivas-Santisteban R.   +4 more
europepmc   +2 more sources

Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]

Kidney Research and Clinical Practice, 2022
Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha   +4 more
doaj   +1 more source

NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]

PLoS ONE, 2013
Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi, Hirokazu Arai, Toshihiko Momiyama   +2 more
doaj   +1 more source

Modulators of Ion Transport in Nasal Polyps: An Measurement of Short-Circuit Current [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesTo examine possible modulators of the ion transport through the apical membrane of the nasal polyps.MethodsThe study was conducted using the freshly-excised nasal polyps from the patients with chronic sinusitis.
Jun Ho Lee, Chae-Seo Rhee, Dae Woo Kim, Chul Hee Lee   +3 more
doaj   +1 more source