Results 1 to 10 of about 13,838 (206)

Erratum to: Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Purinergic Signalling [PDF]

Purinergic Signalling, 2005
F. Kukulski, S.A. Levesque, E.G. Lavoie, J. Lecka, F. Bigonnesse, A.F. Knowles, S.C. Robson, T.L. Kirley & J. Sevigny (2005) Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Purinergic Signalling 1(2): 193–204. On page 194 of the above-mentioned article, in ‘Materials and methods’ under ‘Plasmids,’ second paragraph, the ...
François Bigonnesse, Elise G. Lavoie, Filip Kukulski, Terence L. Kirley, Joanna Lecka, Jean Sévigny, Sébastien A. Lévesque, Aileen F. Knowles, Simon C. Robson   +8 more
semanticscholar   +5 more sources

P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells. [PDF]

Journal of Clinical Investigation, 1992
To develop a new approach to the treatment of advanced, hormone-refractory prostate cancer, the signal transductions regulating the growth of human androgen-independent prostate carcinoma cell lines were studied. Agonist-stimulated Ca2+ mobilization, a critical regulatory event in other secretory cell types, was studied as a means of identifying ...
Jane B. Trepel, Wei-Gang Fang, Farzaneh Pirnia, Charles E. Myers, Yung-Jue Bang   +4 more
semanticscholar   +5 more sources

Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells. [PDF]

Journal of Clinical Investigation, 1991
We have compared the abilities of extracellular ATP (acting via P2-purinergic receptors) and formylated peptides (FMLP) to stimulate both phospholipase D (PLD)-based signal transduction and primary granule (azurophilic) secretion in HL-60 cells induced to differentiate along the granulocytic pathway.
Leila S. Jacobs, Mingsheng Xie, George R. Dubyak   +2 more
semanticscholar   +5 more sources

P2 Purinergic Receptor Agonists Enhance cAMP Production in Madin-Darby Canine Kidney Epithelial Cells via an Autocrine/Paracrine Mechanism [PDF]

Journal of Biological Chemistry, 1996
Mechanisms of cross-talk between different classes of signaling molecules are inadequately understood. We have used clonal Madin-Darby canine kidney (MDCK-D1) epithelial cells as a model system to investigate the effects of extracellular nucleotides (e.g. ATP, UTP), which promote increase in activity of several phospholipases, on cAMP production.
Paul A. Insel, Steven R. Post, J. Paul Jacobson   +2 more
openaire   +5 more sources

Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. [PDF]

PLoS ONE, 2012
Previously, we demonstrated that nucleotides released upon mechanical injury to corneal epithelium activate purinergic (P2) receptors resulting in mobilization of a Ca(2+) wave.
Duane J Oswald, Albert Lee, Monique Trinidad, Cheryl Chi, Ruiyi Ren, Celeste B Rich, Vickery Trinkaus-Randall   +6 more
doaj   +2 more sources

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]

J Innate Immun
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Forde L, Gogoi D, Baird R, McCarthy C, Keane MP, Reeves EP, McGrath EE.   +6 more
europepmc   +2 more sources

Purinergic receptors in ocular inflammation [PDF]

Mediators of Inflammation, 2014
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly 'tuned,' can lead to disease.
Diebold, Y., Gasull Casanova, Xavier, Guzman-Aranguez, A., Pintor, Jesús J.   +3 more
core   +10 more sources

ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4. [PDF]

PLoS ONE, 2012
Brain-derived neurotrophic factor (BDNF), a neuromodulator involved in nociceptive hypersensitivity in the central nervous system, is also expressed in synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients.
Kerstin Klein, André Aeschlimann, Suzana Jordan, Renate Gay, Steffen Gay, Haiko Sprott   +5 more
doaj   +2 more sources

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy. [PDF]

MedComm (2020)
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Illes P, Rubini P, Ulrich H, Yin HY, Tang Y.   +4 more
europepmc   +2 more sources

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. [PDF]

PLoS ONE, 2015
Infection by the protozoan parasite Toxoplasma gondii is highly prevalent worldwide and may have serious clinical manifestations in immunocompromised patients. T. gondii is an obligate intracellular parasite that infects almost any cell type in mammalian
Aline Cristina Abreu Moreira-Souza, Ygor Marinho, Gladys Correa, Giani França Santoro, Claudia Mara Lara Melo Coutinho, Rossiane Claudia Vommaro, Robson Coutinho-Silva   +6 more
doaj   +1 more source