Results 1 to 10 of about 4,105 (107)

P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells. [PDF]

Journal of Clinical Investigation, 1992
To develop a new approach to the treatment of advanced, hormone-refractory prostate cancer, the signal transductions regulating the growth of human androgen-independent prostate carcinoma cell lines were studied. Agonist-stimulated Ca2+ mobilization, a critical regulatory event in other secretory cell types, was studied as a means of identifying ...
W G, Fang, F, Pirnia, Y J, Bang, C E, Myers, J B, Trepel   +4 more
openaire   +3 more sources

Erratum to: Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Purinergic Signalling [PDF]

Purinergic Signalling, 2005
F. Kukulski, S.A. Levesque, E.G. Lavoie, J. Lecka, F. Bigonnesse, A.F. Knowles, S.C. Robson, T.L. Kirley & J. Sevigny (2005) Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Purinergic Signalling 1(2): 193–204. On page 194 of the above-mentioned article, in ‘Materials and methods’ under ‘Plasmids,’ second paragraph, the ...
Kukulski, F., Levesque, S.A., Lavoie, E.G., Lecka, J., Bigonnesse, F., Knowles, A.F., Robson, S.C., Kirley, T.L., Sevigny, J.   +8 more
openaire   +3 more sources

P2 Purinergic Receptor Agonists Enhance cAMP Production in Madin-Darby Canine Kidney Epithelial Cells via an Autocrine/Paracrine Mechanism [PDF]

Journal of Biological Chemistry, 1996
Mechanisms of cross-talk between different classes of signaling molecules are inadequately understood. We have used clonal Madin-Darby canine kidney (MDCK-D1) epithelial cells as a model system to investigate the effects of extracellular nucleotides (e.g. ATP, UTP), which promote increase in activity of several phospholipases, on cAMP production.
S R, Post, J P, Jacobson, P A, Insel
openaire   +4 more sources

Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells. [PDF]

Journal of Clinical Investigation, 1991
We have compared the abilities of extracellular ATP (acting via P2-purinergic receptors) and formylated peptides (FMLP) to stimulate both phospholipase D (PLD)-based signal transduction and primary granule (azurophilic) secretion in HL-60 cells induced to differentiate along the granulocytic pathway.
M S, Xie, L S, Jacobs, G R, Dubyak
openaire   +3 more sources

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]

Journal of Innate Immunity
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde, Debananda Gogoi, Rory Baird, Cormac McCarthy, Michael P. Keane, Emer P. Reeves, Emmet E. McGrath   +6 more
doaj   +2 more sources

0099 INFUSION OF A PURINERGIC P2 RECEPTOR AGONIST INTO THE BASAL FOREBRAIN BY REVERSE MICRODIALYSIS ATTENUATES HOMEOSTATIC SLEEP REBOUND [PDF]

Sleep, 2017
C Yang, A Kalinchuk, KA Jacobson, S Winston, JT McKenna, RW McCarley, RE Strecker, R Basheer, RE Brown   +8 more
openaire   +2 more sources

Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. [PDF]

PLoS ONE, 2012
Previously, we demonstrated that nucleotides released upon mechanical injury to corneal epithelium activate purinergic (P2) receptors resulting in mobilization of a Ca(2+) wave.
Duane J Oswald, Albert Lee, Monique Trinidad, Cheryl Chi, Ruiyi Ren, Celeste B Rich, Vickery Trinkaus-Randall   +6 more
doaj   +1 more source

ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4. [PDF]

PLoS ONE, 2012
Brain-derived neurotrophic factor (BDNF), a neuromodulator involved in nociceptive hypersensitivity in the central nervous system, is also expressed in synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients.
Kerstin Klein, André Aeschlimann, Suzana Jordan, Renate Gay, Steffen Gay, Haiko Sprott   +5 more
doaj   +1 more source

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. [PDF]

PLoS ONE, 2015
Infection by the protozoan parasite Toxoplasma gondii is highly prevalent worldwide and may have serious clinical manifestations in immunocompromised patients. T. gondii is an obligate intracellular parasite that infects almost any cell type in mammalian
Aline Cristina Abreu Moreira-Souza, Ygor Marinho, Gladys Correa, Giani França Santoro, Claudia Mara Lara Melo Coutinho, Rossiane Claudia Vommaro, Robson Coutinho-Silva   +6 more
doaj   +1 more source

P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

Frontiers in Pharmacology, 2020
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Lucas T. Woods, Lucas T. Woods, Kimberly J. Jasmer, Kimberly J. Jasmer, Kevin Muñoz Forti, Kevin Muñoz Forti, Jean M. Camden, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman, Gary A. Weisman   +15 more
doaj   +1 more source