Results 91 to 100 of about 13,838 (206)
Regulatory mechanisms of surfactant secretion [PDF]
, 1998 Surfactant secretion is a critical regulated process in the metabolism of pulmonary surfactant. Presumably, because this process is vital to the survival of the organism, there are several independent pathways for stimulating secretion which work through
Mason, Robert J., Voelker, Dennis R.
core +1 more source
Potential pharmaceuticals targeting neuroimmune interactions in treating acute lung injury
Clinical and Translational Medicine, Volume 14, Issue 8, August 2024.1. The lungs present abundant nerve innervations. 2. Neuroimmune interactions exert a modulatory effect in the onset and progression of lung inflammatory diseases, especially acute lung injury (ALI). 3. The advancements of potential drugs for ALI targeting neuroimmune crosstalk at different stages from preclinical investigation to clinical trials are ...
Di Wu +5 more
wiley +1 more source
Towards monitoring conformational changes of the GPCR neurotensin receptor 1 by single-molecule FRET [PDF]
arXiv, 2018 Neurotensin receptor 1 (NTSR1) is a G protein-coupled receptor that is important for signaling in the brain and the gut. Its agonist ligand neurotensin (NTS), a 13-amino-acid peptide, binds with nanomolar affinity from the extracellular side to NTSR1 and induces conformational changes that trigger intracellular signaling processes.
arxiv
The platelet ATP and ADP receptors. [PDF]
, 2006 peer reviewedThis review focuses on recent findings on the physiology of these platelet ADP and ATP receptors, their distinct downstream intracellular signaling pathways as well as on the available agonists, antagonists and inhibitors that allow their ...
Hoylaerts, Marc F +3 more
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Glia, Volume 72, Issue 6, Page 1016-1053, June 2024.Main Points Microglia respond to brain ischemia to restore lost homeostasis. Ischemia generates heterogenous microglia states that could engage in diverse functions. Proliferating microglia promote tissue repair whereas some microglia undergo dysfunction.
Anna M. Planas
wiley +1 more source
Journal of Toxicological Sciences, 2014 Resident macrophages in the liver (Kupffer cells) produce various cytokines and chemokines, and have important roles in hepatitis and liver fibrosis. The cells are activated by various factors, for example lipopolysaccharide (LPS), which is an endotoxin ...
M. Ishimaru +6 more
semanticscholar +1 more source
The role of dinucleoside polyphosphates on the ocular surface and other eye structures [PDF]
, 2016 Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present
Carracedo Rodríguez, Juan Gonzalo +3 more
core +1 more source
Mapping the intramolecular signal transduction of G-protein coupled receptors [PDF]
Proteins: Struct. Funct. Bioinfo. 2013, 2013 G-protein coupled receptors (GPCRs), a major gatekeeper of extracellular signals on plasma membrane, are unarguably one of the most important therapeutic targets. Given the recent discoveries of allosteric modulations, an allosteric wiring diagram of intramolecular signal transductions would be of great use to glean the mechanism of receptor regulation.
arxiv
Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala [PDF]
Research Results in Pharmacology 10(1): 1-6 (2024)Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580 on the spiking activity of pyramidal neurons in the BLA to shed light on the complex interplay ...
arxiv +1 more source
P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]
, 1998 The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Barnard, EA +3 more
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