Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]
, 2016 P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean +3 more
core +1 more source
The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression [PDF]
, 2018 Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus.
Burnstock, G, Knight, GE
core +2 more sources
Functions of Purinergic Receptors [PDF]
, 2019 Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules found in many mammalian tissues. Purinergic receptors are transmembrane receptors consisting of two main categories.
Sarikaya, Eren
core +2 more sources
Release of ATP from avian Müller glia cells in culture [PDF]
, 2011 ATP can be released from neurons and act as a neuromodulator in the nervous system. Besides neurons, cortical astrocytes also are capable of releasing ATP from acidic vesicles in a Ca2+-dependent way.
Loiola, Erick Correia +1 more
core +1 more source
Dwell time of a Brownian interacting molecule in a cellular microdomain [PDF]
arXiv, 2006 The time spent by an interacting Brownian molecule inside a bounded microdomain has many applications in cellular biology, because the number of bounds is a quantitative signal, which can initiate a cascade of chemical reactions and thus has physiological consequences.
arxiv
Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]
, 2019 Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
core +1 more source
Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo [PDF]
, 2011 In the healthy adult brain microglia, the main immune-competent cells of the CNS, have a distinct (so-called resting or surveying) phenotype. Resting microglia can only be studied in vivo since any isolation of brain tissue inevitably triggers microglial
Brawek, Bianca +2 more
core +1 more source
Computational Study of Molecular Mechanisms of Caffeine Actions [PDF]
arXiv, 2015 Caffeine (CAF) is one of the most widely and regularly consumed biologically active substances. We use computer simulation approach to the study of CAF activity by searching for its possible complexes with biopolymer fragments. The principal CAF target at physiologically important concentrations refers to adenosine receptors.
arxiv
IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF GPCR23/LPA4 AS A CANDIDATE G PROTEIN-COUPLED RECEPTOR FOR GUANOSINE [PDF]
, 2014 La guanosina esercita diverse funzioni a livello del Sistema Nervoso Centrale, coinvolgendo recettori di membrana accoppiati a proteine G (GPCR) non ancora identificati.
GRILLO, Maria
core
Extracellular-to-intracellular signal transfer via G-proteins [PDF]
arXiv, 2005 We look at the problem of signal transduction by extracellular agonist binding to a receptor protein at the membrane (sensor) via binding of G-proteins (effectors) to a highly integrative target molecule, such as the second messenger cAMP (target). We explore the effects of binding times, effector assignment and effector pool size on the shape of the ...
arxiv