Results 171 to 180 of about 13,838 (206)

Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.

The Journal of Pharmacology and Experimental Therapeutics, 1996
ATP produces significant cardiovascular effects by activation of P2 purinoceptors. In the present study, we examined the regional hemodynamic profiles produced by intravenous administration of a P2X and a P2Y purinergic receptor agonist. Sprague-Dawley rats were anesthetized with Inactin, catheters were placed in the femoral artery and vein and the ...
B F, Cox, G J, Smits
semanticscholar   +4 more sources

Chronic Treatment With P2-Purinergic Receptor Agonists Induces Phenotypic Modulation of the HL-60 and U937 Human Myelogenous Leukemia Cell Lines

Journal of Leukocyte Biology, 1991
Abstract In previous studies we have demonstrated that extracellular ATP (and UTP), acting through P2-purinergic receptors, can stimulate the inositol phospholipid signaling system in neutrophils and monocytes, as well as in neutrophil monocyte progenitor cells.
George R. Dubyak, Melvin Berger, Daniel S. Cowen, Louise C. Nuttle   +3 more
semanticscholar   +5 more sources

ChemInform Abstract: The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2‐Purinergic Receptors.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Juta K. Reed, Girolamo Tusa
  +7 more sources

Sensitization of adenylyl cyclase by P2 purinergic and M5 muscarinic receptor agonists in L cells.

Molecular pharmacology, 1991
Many hormones have been shown to activate phospholipase C, which results in the hydrolysis of membrane polyphosphoinositides, such as phosphatidylinositol 4,5-bisphosphate (PIP2). Two second messengers are known to be produced by PIP2 hydrolysis, 1,2-diacylglycerol, an endogenous activator of a family of enzymes called protein kinase C (PKCs), and ...
J A, Johnson, J, Friedman, R D, Halligan, M, Birnbaumer, R B, Clark   +4 more
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Unveiling the agonistic properties of Preyssler-type Polyoxotungstates on purinergic P2 receptors

Journal of Inorganic Biochemistry
The Preyssler-type polyoxotungstate ({P5W30}) belongs to the family of polyanionic metal-oxides formed by group V and VI metal ions, such as V, Mo and W, commonly known as polyoxometalates (POMs). POMs have demonstrated inhibitory effect on a significant number of ATP-binding proteins in vitro.
Poejo, Joana, Gumerova, Nadiia I., Rompel, Annette, Mata, Ana M., Aureliano, Manuel, Gutierrez-Merino, Carlos   +5 more
openaire   +3 more sources

P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes.

Journal of applied physiology, 1989
Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas
D. Warburton, S. Buckley, L. Cosico
semanticscholar   +1 more source

Modulation of P2 receptors on pancreatic β-cells by agonists and antagonists: a molecular target for type 2 diabetes treatment.

Current Diabetes Reviews, 2013
Morbidity and mortality from diabetes mellitus (DM) are serious worldwide concerns. By the year 2030, the estimated number of diabetic patients will reach a staggering 439 million worldwide.
P. F. Pacheco, L. Ferreira, L. A. Alves, R. Faria   +3 more
semanticscholar   +1 more source

A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.

Science, 1990
The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric
S. Gupta, E. Diez, L. Heasley, S. Osawa, G. Johnson   +4 more
semanticscholar   +1 more source

Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells.

Biochemical and Biophysical Research Communications - BBRC, 1998
Primary cell cultures of human colorectal carcinomas were established and characterized immunocytochemically. In the isolated cancer cells intracellular Ca2+ concentrations ([Ca2+]i) were measured by the fura-2 method.
M. Höpfner, K. Lemmer, A. Jansen, C. Hanski, E. Riecken, M. Gavish, B. Mann, H. Buhr, G. Glassmeier, H. Scherübl   +9 more
semanticscholar   +1 more source