Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies
Advanced Science, Volume 12, Issue 11, March 20, 2025.This review systematically presents an updated and comprehensive overview of transfusion‐related acute lung injury (TRALI), a serious complication of blood transfusions. It explores TRALI's clinical features, potential causes, and immune mechanisms. Key insights include the roles of signaling pathways and possible therapies, with a focus on prevention ...
Xiaobin Fang +5 more
wiley +1 more source
General Chemical Reaction Network Theory for Olfactory Sensing Based on G-Protein-Coupled Receptors : Elucidation of Odorant Mixture Effects and Agonist-Synergist Threshold [PDF]
arXiv, 2023 This work presents a general chemical reaction network theory for olfactory sensing processes that employ G-protein-coupled receptors as olfactory receptors (ORs). The theory is applicable to general mixtures of odorants and an arbitrary number of ORs.
arxiv
Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries [PDF]
, 2014 Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than UDP ...
Alsaqati, M. +3 more
core +3 more sources
TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate
British Journal of Pharmacology, Volume 182, Issue 6, Page 1324-1340, March 2025.Background and Purpose Abdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated in the pathogenesis of abdominal pain, the relative paucity of TRPV4 expression in colon‐projecting sensory neurons suggests that non‐neuronal
Michelle Y. Meng +14 more
wiley +1 more source
P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]
, 2011 Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core +1 more source
Mechanisms of comorbidity between Alzheimer's disease and pain
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management.
Kaifang Yao +12 more
wiley +1 more source
The affinity-efficacy problem: an essential part of pharmacology education [PDF]
R Soc Open Sci. 2024 Jul 24;11(7):240487. PMID: 39050724; PMCID:
PMC11267233A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist. These properties are inextricably linked and cannot be easily separated in any case where the binding of a ligand induces a conformation change in its receptor.
arxiv +1 more source
Purinergic and Adrenergic Agonists Synergize in Stimulating Vasopressin and Oxytocin Release
Journal of Neuroscience, 2000 The A1 catecholamine neurons of the caudal ventrolateral medulla transmit hemodynamic information to the vasopressin (VP) neurons in the hypothalamus. These neurons corelease ATP with norepinephrine.
J. Kapoor, C. Sladek
semanticscholar +1 more source
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
core +1 more source
The Role of Ion Channels in Pulmonary Hypertension: A Review
Pulmonary Circulation, Volume 15, Issue 1, January 2025.ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH.
Han‐Fei Li +11 more
wiley +1 more source