Results 71 to 80 of about 13,838 (206)
Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging [PDF]
Mol Biol Cell. 2018 Nov 1; 29(22): 2720-2736, 2019 To observe internalization of the yeast pheromone receptor Ste2 by fluorescence microscopy in live cells in real time, we visualized only those molecules present at the cell surface at the time of agonist engagement (rather than the total cellular pool) by tagging this receptor at its N-terminus with an exocellular fluorogen-activating protein (FAP). A
arxiv +1 more source
Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]
, 2008 Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core
Role of inflammasomes and neuroinflammation in epilepsy
Immunological Reviews, Volume 329, Issue 1, January 2025.Summary Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of abnormal electrical activity in the brain and involuntary movement that can lead to physical injury and loss of consciousness. Seizures are canonically accompanied by increased inflammatory cytokine production that promotes neuroinflammation, brain ...
Ava Hollis, John R. Lukens
wiley +1 more source
UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery [PDF]
, 2018 Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides.
Abbas, Zainab S.B. +6 more
core +2 more sources
Research progress of microglial surface receptors in perioperative neurocognitive disorders
Ibrain, Volume 10, Issue 4, Page 450-461, Winter 2024.Perioperative factors such as surgical trauma, anesthetic, and inflammatory factors act on microglia in the brain. The receptor on microglia is activated to promote or inhibit the occurrence of inflammatory reactions, which, in turn, induce or prevent the occurrence of perioperative neurocognitive disorder (PND).
Chun‐Chun Tang +2 more
wiley +1 more source
Molecular Cancer, 2015 One of the challenging problems of current radio-chemotherapy is recurrence and metastasis of cancer cells that survive initial treatment. We propose that one of the unwanted effects of radiochemotherapy is the release from damaged (“leaky”) cells of ...
Gabriela Schneider +7 more
semanticscholar +1 more source
The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance [PDF]
, 2011 Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized.
Robson, Simon Christopher +2 more
core +1 more source
Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases
Brain and Behavior, Volume 14, Issue 11, November 2024.Dexmedetomidine has demonstrated potent neuroprotective effects in a variety of brain disorders, and this may be achieved by inhibiting inflammatory responses, attenuating oxidative stress, reducing apoptosis and autophagy, and improving the immune microenvironment.
Zhenxing Tao, Pengpeng Li, Xudong Zhao
wiley +1 more source
Purinergic Signalling Purinergic Signalling, 2017 Epithelial to mesenchymal transition (EMT) occurs during embryogenesis or under pathological conditions such as hypoxia, injury, chronic inflammation, or tissue fibrosis.
M. Zuccarini +12 more
semanticscholar +1 more source
Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries [PDF]
, 2013 Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries.
Alsaqati, M. +2 more
core +3 more sources